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Erratum: A new antibiotic kills pathogens without detectable resistance.
Ling LL, Schneider T, Peoples AJ, Spoering AL, Engels I, Conlon BP, Mueller A, Schäberle TF, Hughes DE, Epstein S, Jones M, Lazarides L, Steadman VA, Cohen DR, Felix CR, Fetterman KA, Millett WP, Nitti AG, Zullo AM, Chen C, Lewis K. Ling LL, et al. Among authors: epstein s. Nature. 2015 Apr 16;520(7547):388. doi: 10.1038/nature14303. Epub 2015 Feb 25. Nature. 2015. PMID: 25731174 No abstract available.
A new antibiotic kills pathogens without detectable resistance.
Ling LL, Schneider T, Peoples AJ, Spoering AL, Engels I, Conlon BP, Mueller A, Schäberle TF, Hughes DE, Epstein S, Jones M, Lazarides L, Steadman VA, Cohen DR, Felix CR, Fetterman KA, Millett WP, Nitti AG, Zullo AM, Chen C, Lewis K. Ling LL, et al. Among authors: epstein s. Nature. 2015 Jan 22;517(7535):455-9. doi: 10.1038/nature14098. Epub 2015 Jan 7. Nature. 2015. PMID: 25561178 Free PMC article.
Uncultured microorganisms as a source of secondary metabolites.
Lewis K, Epstein S, D'Onofrio A, Ling LL. Lewis K, et al. Among authors: epstein s. J Antibiot (Tokyo). 2010 Aug;63(8):468-76. doi: 10.1038/ja.2010.87. Epub 2010 Jul 21. J Antibiot (Tokyo). 2010. PMID: 20648021 Review.
Lassomycin, a ribosomally synthesized cyclic peptide, kills mycobacterium tuberculosis by targeting the ATP-dependent protease ClpC1P1P2.
Gavrish E, Sit CS, Cao S, Kandror O, Spoering A, Peoples A, Ling L, Fetterman A, Hughes D, Bissell A, Torrey H, Akopian T, Mueller A, Epstein S, Goldberg A, Clardy J, Lewis K. Gavrish E, et al. Among authors: epstein s. Chem Biol. 2014 Apr 24;21(4):509-518. doi: 10.1016/j.chembiol.2014.01.014. Epub 2014 Mar 27. Chem Biol. 2014. PMID: 24684906 Free PMC article.
Microbial scout hypothesis, stochastic exit from dormancy, and the nature of slow growers.
Buerger S, Spoering A, Gavrish E, Leslin C, Ling L, Epstein SS. Buerger S, et al. Among authors: epstein ss. Appl Environ Microbiol. 2012 May;78(9):3221-8. doi: 10.1128/AEM.07307-11. Epub 2012 Feb 24. Appl Environ Microbiol. 2012. PMID: 22367083 Free PMC article.
We recently proposed a scout model of the microbial life cycle (S. S. Epstein, Nature 457:1083, 2009), the central element of which is the hypothesis that dormant microbial cells wake up into active (so-called scout) cells stochastically, independently of env …
We recently proposed a scout model of the microbial life cycle (S. S. Epstein, Nature 457:1083, 2009), the central elem …
Microbial scout hypothesis and microbial discovery.
Buerger S, Spoering A, Gavrish E, Leslin C, Ling L, Epstein SS. Buerger S, et al. Among authors: epstein ss. Appl Environ Microbiol. 2012 May;78(9):3229-33. doi: 10.1128/AEM.07308-11. Epub 2012 Feb 24. Appl Environ Microbiol. 2012. PMID: 22367084 Free PMC article.
Intact DNA in ancient permafrost.
Lewis K, Epstein S, Godoy VG, Hong SH. Lewis K, et al. Among authors: epstein s. Trends Microbiol. 2008 Mar;16(3):92-4. doi: 10.1016/j.tim.2008.01.002. Trends Microbiol. 2008. PMID: 18291656 Review.
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