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Lead optimization toward proof-of-concept tools for Huntington's disease within a 4-(1H-pyrazol-4-yl)pyrimidine class of pan-JNK inhibitors.
Wityak J, McGee KF, Conlon MP, Song RH, Duffy BC, Clayton B, Lynch M, Wang G, Freeman E, Haber J, Kitchen DB, Manning DD, Ismail J, Khmelnitsky Y, Michels P, Webster J, Irigoyen M, Luche M, Hultman M, Bai M, Kuok ID, Newell R, Lamers M, Leonard P, Yates D, Matthews K, Ongeri L, Clifton S, Mead T, Deupree S, Wheelan P, Lyons K, Wilson C, Kiselyov A, Toledo-Sherman L, Beconi M, Muñoz-Sanjuan I, Bard J, Dominguez C. Wityak J, et al. Among authors: irigoyen m. J Med Chem. 2015 Apr 9;58(7):2967-87. doi: 10.1021/jm5013598. Epub 2015 Mar 19. J Med Chem. 2015. PMID: 25760409
Neopyrrolomycins with broad spectrum antibacterial activity.
Hopp DC, Rhea J, Jacobsen D, Romari K, Smith C, Rabenstein J, Irigoyen M, Clarke M, Francis L, Luche M, Carr GJ, Mocek U. Hopp DC, et al. Among authors: irigoyen m. J Nat Prod. 2009 Feb 27;72(2):276-9. doi: 10.1021/np800632f. J Nat Prod. 2009. PMID: 19191549
5-Hydroxy ericamycin, a new anthraquinone with potent antimicrobial activity.
Rhea J, Craig Hopp D, Rabenstein J, Smith C, Lucas S, Romari K, Clarke M, Francis L, Irigoyen M, Luche M, Carr GJ, Mocek U. Rhea J, et al. Among authors: irigoyen m. J Antibiot (Tokyo). 2012 Dec;65(12):623-5. doi: 10.1038/ja.2012.78. Epub 2012 Sep 26. J Antibiot (Tokyo). 2012. PMID: 23010899 No abstract available.
Mutactimycin E, a new anthracycline antibiotic with gram-positive activity.
Hopp DC, Rabenstein J, Rhea J, Smith C, Romari K, Clarke M, Francis L, Irigoyen M, Milanowski D, Luche M, Carr GJ, Mocek U. Hopp DC, et al. Among authors: irigoyen m. J Antibiot (Tokyo). 2008 Nov;61(11):675-9. doi: 10.1038/ja.2008.95. J Antibiot (Tokyo). 2008. PMID: 19168982
Citreamicins with potent gram-positive activity.
Hopp DC, Milanowski DJ, Rhea J, Jacobsen D, Rabenstein J, Smith C, Romari K, Clarke M, Francis L, Irigoyen M, Luche M, Carr GJ, Mocek U. Hopp DC, et al. Among authors: irigoyen m. J Nat Prod. 2008 Dec;71(12):2032-5. doi: 10.1021/np800503z. J Nat Prod. 2008. PMID: 19053507
Rapid Identification of Novel Inhibitors of the Human Aquaporin-1 Water Channel.
Patil RV, Xu S, van Hoek AN, Rusinko A, Feng Z, May J, Hellberg M, Sharif NA, Wax MB, Irigoyen M, Carr G, Brittain T, Brown P, Colbert D, Kumari S, Varadaraj K, Mitra AK. Patil RV, et al. Among authors: irigoyen m. Chem Biol Drug Des. 2016 May;87(5):794-805. doi: 10.1111/cbdd.12713. Epub 2016 Jan 17. Chem Biol Drug Des. 2016. PMID: 26685080 Free PMC article.
Use of risk chart algorithms for the identification of psoriatic arthritis patients at high risk for cardiovascular disease: findings derived from the project CARMA cohort after a 7.5-year follow-up period.
Polo Y La Borda J, Castañeda S, Heras-Recuero E, Sánchez-Alonso F, Plaza Z, García Gómez C, Ferraz-Amaro I, Sanchez-Costa JT, Sánchez-González OC, Turrión-Nieves AI, Perez-Alcalá A, Pérez-García C, González-Juanatey C, Llorca J, Gonzalez-Gay MA; CARMA Project Collaborative Group. Polo Y La Borda J, et al. RMD Open. 2024 Apr 17;10(2):e004207. doi: 10.1136/rmdopen-2024-004207. RMD Open. 2024. PMID: 38631846 Free PMC article.
517 results