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Lead optimization toward proof-of-concept tools for Huntington's disease within a 4-(1H-pyrazol-4-yl)pyrimidine class of pan-JNK inhibitors.
Wityak J, McGee KF, Conlon MP, Song RH, Duffy BC, Clayton B, Lynch M, Wang G, Freeman E, Haber J, Kitchen DB, Manning DD, Ismail J, Khmelnitsky Y, Michels P, Webster J, Irigoyen M, Luche M, Hultman M, Bai M, Kuok ID, Newell R, Lamers M, Leonard P, Yates D, Matthews K, Ongeri L, Clifton S, Mead T, Deupree S, Wheelan P, Lyons K, Wilson C, Kiselyov A, Toledo-Sherman L, Beconi M, Muñoz-Sanjuan I, Bard J, Dominguez C. Wityak J, et al. Among authors: ismail j. J Med Chem. 2015 Apr 9;58(7):2967-87. doi: 10.1021/jm5013598. Epub 2015 Mar 19. J Med Chem. 2015. PMID: 25760409
Synthesis and Biological Evaluation of N-((1-(4-(Sulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide Inhibitors of Glycine Transporter-1.
Cioffi CL, Liu S, Wolf MA, Guzzo PR, Sadalapure K, Parthasarathy V, Loong DT, Maeng JH, Carulli E, Fang X, Karunakaran K, Matta L, Choo SH, Panduga S, Buckle RN, Davis RN, Sakwa SA, Gupta P, Sargent BJ, Moore NA, Luche MM, Carr GJ, Khmelnitsky YL, Ismail J, Chung M, Bai M, Leong WY, Sachdev N, Swaminathan S, Mhyre AJ. Cioffi CL, et al. Among authors: ismail j. J Med Chem. 2016 Sep 22;59(18):8473-94. doi: 10.1021/acs.jmedchem.6b00914. Epub 2016 Sep 9. J Med Chem. 2016. PMID: 27559615 Free article.
PEG-Lipid-PLGA Hybrid Particles for Targeted Delivery of Anti-Inflammatory Drugs.
Ismail J, Klepsch LC, Dahlke P, Tsarenko E, Vollrath A, Pretzel D, Jordan PM, Rezaei K, Czaplewska JA, Stumpf S, Beringer-Siemers B, Nischang I, Hoeppener S, Werz O, Schubert US. Ismail J, et al. Pharmaceutics. 2024 Jan 28;16(2):187. doi: 10.3390/pharmaceutics16020187. Pharmaceutics. 2024. PMID: 38399248 Free PMC article.
Cell-type-directed design of synthetic enhancers.
Taskiran II, Spanier KI, Dickmänken H, Kempynck N, Pančíková A, Ekşi EC, Hulselmans G, Ismail JN, Theunis K, Vandepoel R, Christiaens V, Mauduit D, Aerts S. Taskiran II, et al. Among authors: ismail jn. Nature. 2024 Feb;626(7997):212-220. doi: 10.1038/s41586-023-06936-2. Epub 2023 Dec 12. Nature. 2024. PMID: 38086419 Free PMC article.
Multiple Electrolytes Solution Versus Saline as Bolus Fluid for Resuscitation in Pediatric Septic Shock: A Multicenter Randomized Clinical Trial.
Sankar J, Muralidharan J, Lalitha AV, Rameshkumar R, Pathak M, Das RR, Nadkarni VM, Ismail J, Subramanian M, Nallasamy K, Dev N, Kumar UV, Kumar K, Sharma T, Jaravta K, Thakur N, Aggarwal P, Jat KR, Kabra SK, Lodha R. Sankar J, et al. Among authors: ismail j. Crit Care Med. 2023 Nov 1;51(11):1449-1460. doi: 10.1097/CCM.0000000000005952. Epub 2023 Jun 9. Crit Care Med. 2023. PMID: 37294145 Clinical Trial.
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