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Lead optimization toward proof-of-concept tools for Huntington's disease within a 4-(1H-pyrazol-4-yl)pyrimidine class of pan-JNK inhibitors.
J Med Chem. 2015 Apr 9;58(7):2967-87. doi: 10.1021/jm5013598. Epub 2015 Mar 19.
J Med Chem. 2015.
PMID: 25760409
Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 8. Pharmacological optimization of orally bioavailable 2-pyridone-containing peptidomimetics.
Dragovich PS, Prins TJ, Zhou R, Johnson TO, Hua Y, Luu HT, Sakata SK, Brown EL, Maldonado FC, Tuntland T, Lee CA, Fuhrman SA, Zalman LS, Patick AK, Matthews DA, Wu EY, Guo M, Borer BC, Nayyar NK, Moran T, Chen L, Rejto PA, Rose PW, Guzman MC, Dovalsantos EZ, Lee S, McGee K, Mohajeri M, Liese A, Tao J, Kosa MB, Liu B, Batugo MR, Gleeson JP, Wu ZP, Liu J, Meador JW 3rd, Ferre RA.
Dragovich PS, et al.
J Med Chem. 2003 Oct 9;46(21):4572-85. doi: 10.1021/jm030166l.
J Med Chem. 2003.
PMID: 14521419
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Discovery of (3S,3aR)-2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic acid (PF-3882845), an orally efficacious mineralocorticoid receptor (MR) antagonist for hypertension and nephropathy.
Meyers MJ, Arhancet GB, Hockerman SL, Chen X, Long SA, Mahoney MW, Rico JR, Garland DJ, Blinn JR, Collins JT, Yang S, Huang HC, McGee KF, Wendling JM, Dietz JD, Payne MA, Homer BL, Heron MI, Reitz DB, Hu X.
Meyers MJ, et al. Among authors: mcgee kf.
J Med Chem. 2010 Aug 26;53(16):5979-6002. doi: 10.1021/jm100505n.
J Med Chem. 2010.
PMID: 20672822
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A [4 + 4] 2-pyridone approach to taxol. 3. Stereocontrol during elaboration of the cyclooctane.
Lee YG, McGee KF Jr, Chen J, Rucando D, Sieburth SM.
Lee YG, et al. Among authors: mcgee kf jr.
J Org Chem. 2000 Oct 6;65(20):6676-81. doi: 10.1021/jo005532c.
J Org Chem. 2000.
PMID: 11052118
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Photoreactivity of 2-pyridones with furan, benzene, and naphthalene. Inter- and intramolecular photocycloadditions.
Sieburth SM, McGee KF Jr, Zhang F, Chen Y.
Sieburth SM, et al. Among authors: mcgee kf jr.
J Org Chem. 2000 Apr 7;65(7):1972-7. doi: 10.1021/jo9918394.
J Org Chem. 2000.
PMID: 10774015
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Solvent-dependent stereoselectivity of bis-2-pyridone [4 + 4] photocycloaddition is due to H-bonded dimers.
Sieburth SM, McGee KF Jr.
Sieburth SM, et al. Among authors: mcgee kf jr.
Org Lett. 1999 Dec 2;1(11):1775-7. doi: 10.1021/ol991058p.
Org Lett. 1999.
PMID: 10836037
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Studies in bicyclo[3.1.0]hexane methanolysis. Ring opening of activated cyclopropanes under acidic and basic conditions.
Lim YH, McGee KF Jr, Sieburth SM.
Lim YH, et al. Among authors: mcgee kf jr.
J Org Chem. 2002 Sep 6;67(18):6535-8. doi: 10.1021/jo025909+.
J Org Chem. 2002.
PMID: 12201777
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