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The tyrosine kinase inhibitors imatinib and dasatinib reduce myeloid suppressor cells and release effector lymphocyte responses.
Christiansson L, Söderlund S, Mangsbo S, Hjorth-Hansen H, Höglund M, Markevärn B, Richter J, Stenke L, Mustjoki S, Loskog A, Olsson-Strömberg U. Christiansson L, et al. Among authors: loskog a. Mol Cancer Ther. 2015 May;14(5):1181-91. doi: 10.1158/1535-7163.MCT-14-0849. Epub 2015 Mar 11. Mol Cancer Ther. 2015. PMID: 25761894
AdCD40L immunogene therapy for bladder carcinoma--the first phase I/IIa trial.
Malmström PU, Loskog AS, Lindqvist CA, Mangsbo SM, Fransson M, Wanders A, Gårdmark T, Tötterman TH. Malmström PU, et al. Among authors: loskog as. Clin Cancer Res. 2010 Jun 15;16(12):3279-87. doi: 10.1158/1078-0432.CCR-10-0385. Epub 2010 May 4. Clin Cancer Res. 2010. PMID: 20448220 Clinical Trial.
Both CD4+ FoxP3+ and CD4+ FoxP3- T cells from patients with B-cell malignancy express cytolytic markers and kill autologous leukaemic B cells in vitro.
Lindqvist CA, Christiansson LH, Thörn I, Mangsbo S, Paul-Wetterberg G, Sundström C, Tötterman TH, Simonsson B, Enblad G, Frisk P, Olsson-Strömberg U, Loskog AS. Lindqvist CA, et al. Among authors: loskog as. Immunology. 2011 Jul;133(3):296-306. doi: 10.1111/j.1365-2567.2011.03439.x. Epub 2011 Apr 5. Immunology. 2011. PMID: 21463298 Free PMC article.
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