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Base-modified thymidines capable of terminating DNA synthesis are novel bioactive compounds with activity in cancer cells.
Bioorg Med Chem. 2015 Apr 15;23(8):1869-81. doi: 10.1016/j.bmc.2015.01.057. Epub 2015 Feb 14.
Bioorg Med Chem. 2015.
PMID: 25778768
Free PMC article.
Excessive Reactive Oxygen Species and Exotic DNA Lesions as an Exploitable Liability.
AbdulSalam SF, Thowfeik FS, Merino EJ.
AbdulSalam SF, et al.
Biochemistry. 2016 Sep 27;55(38):5341-52. doi: 10.1021/acs.biochem.6b00703. Epub 2016 Sep 13.
Biochemistry. 2016.
PMID: 27582430
Free PMC article.
Review.
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Self-Cyclizing Antioxidants to Prevent DNA Damage Caused by Hydroxyl Radical.
AbdulSalam SF, Gurjar PN, Zhu H, Liu J, Johnson ES, Kadekaro AL, Landero-Figueroa J, Merino EJ.
AbdulSalam SF, et al.
Chembiochem. 2017 Oct 18;18(20):2007-2011. doi: 10.1002/cbic.201700341. Epub 2017 Aug 30.
Chembiochem. 2017.
PMID: 28810083
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A ROS-Activatable Agent Elicits Homologous Recombination DNA Repair and Synergizes with Pathway Compounds.
Thowfeik FS, AbdulSalam SF, Wunderlich M, Wyder M, Greis KD, Kadekaro AL, Mulloy JC, Merino EJ.
Thowfeik FS, et al. Among authors: abdulsalam sf.
Chembiochem. 2015 Nov;16(17):2513-21. doi: 10.1002/cbic.201500304. Epub 2015 Nov 2.
Chembiochem. 2015.
PMID: 26419938
Free PMC article.
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UV cell stress induces oxidative cyclization of a protective reagent for DNA damage reduction in skin explants.
Liu J, Zhu H, Premnauth G, Earnest KG, Hahn P, Gray G, Queenan JA, Prevette LE, AbdulSalam SF, Kadekaro AL, Merino EJ.
Liu J, et al. Among authors: abdulsalam sf.
Free Radic Biol Med. 2019 Apr;134:133-138. doi: 10.1016/j.freeradbiomed.2018.12.037. Epub 2018 Dec 31.
Free Radic Biol Med. 2019.
PMID: 30605714
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Oxidative Cyclization-Induced Activation of a Phosphoinositide 3-Kinase Inhibitor for Enhanced Selectivity of Cancer Chemotherapeutics.
Zhu H, Mishra R, Yuan L, Abdul Salam SF, Liu J, Gray G, Sterling AD, Wunderlich M, Landero-Figueroa J, Garrett JT, Merino EJ.
Zhu H, et al.
ChemMedChem. 2019 Nov 20;14(22):1933-1939. doi: 10.1002/cmdc.201900481. Epub 2019 Nov 7.
ChemMedChem. 2019.
PMID: 31696673
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Utilization of Reactive Oxygen Species Targeted Therapy to Prolong the Efficacy of BRAF Inhibitors in Melanoma.
Yuan L, Mishra R, Patel H, Abdulsalam S, Greis KD, Kadekaro AL, Merino EJ, Garrett JT.
Yuan L, et al.
J Cancer. 2018 Nov 24;9(24):4665-4676. doi: 10.7150/jca.27295. eCollection 2018.
J Cancer. 2018.
PMID: 30588251
Free PMC article.
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Design of a hydrogen peroxide-activatable agent that specifically targets cancer cells.
Vadukoot AK, AbdulSalam SF, Wunderlich M, Pullen ED, Landero-Figueroa J, Mulloy JC, Merino EJ.
Vadukoot AK, et al. Among authors: abdulsalam sf.
Bioorg Med Chem. 2014 Dec 15;22(24):6885-92. doi: 10.1016/j.bmc.2014.10.029. Epub 2014 Oct 30.
Bioorg Med Chem. 2014.
PMID: 25464887
Free PMC article.
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