Houghten RA - Search Results

1

Combinatorial Libraries As a Tool for the Discovery of Novel, Broad-Spectrum Antibacterial Agents Targeting the ESKAPE Pathogens.

Fleeman R, LaVoi TM, Santos RG, Morales A, Nefzi A, Welmaker GS, Medina-Franco JL, Giulianotti MA, Houghten RA, Shaw LN. Fleeman R, et al. Among authors: houghten ra. J Med Chem. 2015 Apr 23;58(8):3340-55. doi: 10.1021/jm501628s. Epub 2015 Apr 1. J Med Chem. 2015. PMID: 25780985 Free PMC article.

2

Identification, structure-activity relationships and molecular modeling of potent triamine and piperazine opioid ligands.

Yongye AB, Appel JR, Giulianotti MA, Dooley CT, Medina-Franco JL, Nefzi A, Houghten RA, Martínez-Mayorga K. Yongye AB, et al. Among authors: houghten ra. Bioorg Med Chem. 2009 Aug 1;17(15):5583-97. doi: 10.1016/j.bmc.2009.06.026. Epub 2009 Jun 21. Bioorg Med Chem. 2009. PMID: 19576786 Free PMC article.

3

Integrating computational and mixture-based screening of combinatorial libraries.

Yongye AB, Pinilla C, Medina-Franco JL, Giulianotti MA, Dooley CT, Appel JR, Nefzi A, Scior T, Houghten RA, Martínez-Mayorga K. Yongye AB, et al. Among authors: houghten ra. J Mol Model. 2011 Jun;17(6):1473-82. doi: 10.1007/s00894-010-0850-1. Epub 2010 Sep 21. J Mol Model. 2011. PMID: 20853183

4

Integrating virtual screening and combinatorial chemistry for accelerated drug discovery.

López-Vallejo F, Caulfield T, Martínez-Mayorga K, Giulianotti MA, Nefzi A, Houghten RA, Medina-Franco JL. López-Vallejo F, et al. Among authors: houghten ra. Comb Chem High Throughput Screen. 2011 Jul;14(6):475-87. doi: 10.2174/138620711795767866. Comb Chem High Throughput Screen. 2011. PMID: 21521151 Review.

5

Selective agonists and antagonists of formylpeptide receptors: duplex flow cytometry and mixture-based positional scanning libraries.

Pinilla C, Edwards BS, Appel JR, Yates-Gibbins T, Giulianotti MA, Medina-Franco JL, Young SM, Santos RG, Sklar LA, Houghten RA. Pinilla C, et al. Among authors: houghten ra. Mol Pharmacol. 2013 Sep;84(3):314-24. doi: 10.1124/mol.113.086595. Epub 2013 Jun 20. Mol Pharmacol. 2013. PMID: 23788657 Free PMC article.

6

Scaffold ranking and positional scanning utilized in the discovery of nAChR-selective compounds suitable for optimization studies.

Wu J, Zhang Y, Maida LE, Santos RG, Welmaker GS, LaVoi TM, Nefzi A, Yu Y, Houghten RA, Toll L, Giulianotti MA. Wu J, et al. Among authors: houghten ra. J Med Chem. 2013 Dec 27;56(24):10103-17. doi: 10.1021/jm401543h. Epub 2013 Dec 12. J Med Chem. 2013. PMID: 24274400 Free PMC article.

7

Novel pyrrolidine diketopiperazines selectively inhibit melanoma cells via induction of late-onset apoptosis.

Onwuha-Ekpete L, Tack L, Knapinska A, Smith L, Kaushik G, Lavoi T, Giulianotti M, Houghten RA, Fields GB, Minond D. Onwuha-Ekpete L, et al. Among authors: houghten ra. J Med Chem. 2014 Feb 27;57(4):1599-608. doi: 10.1021/jm4019542. Epub 2014 Feb 5. J Med Chem. 2014. PMID: 24471466 Free PMC article.

8

SAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) and Application as Selective in Vitro Probes.

Knapinska AM, Dreymuller D, Ludwig A, Smith L, Golubkov V, Sohail A, Fridman R, Giulianotti M, LaVoi TM, Houghten RA, Fields GB, Minond D. Knapinska AM, et al. Among authors: houghten ra. J Med Chem. 2015 Aug 13;58(15):5808-24. doi: 10.1021/acs.jmedchem.5b00354. Epub 2015 Aug 4. J Med Chem. 2015. PMID: 26192023 Free PMC article.

9

Direct Phenotypic Screening in Mice: Identification of Individual, Novel Antinociceptive Compounds from a Library of 734,821 Pyrrolidine Bis-piperazines.

Houghten RA, Ganno ML, McLaughlin JP, Dooley CT, Eans SO, Santos RG, LaVoi T, Nefzi A, Welmaker G, Giulianotti MA, Toll L. Houghten RA, et al. ACS Comb Sci. 2016 Jan 11;18(1):51-64. doi: 10.1021/acscombsci.5b00126. Epub 2016 Jan 5. ACS Comb Sci. 2016. PMID: 26651386 Free PMC article.

10

Identification of 5,6-dihydroimidazo[2,1-b]thiazoles as a new class of antimicrobial agents.

Li Y, Bionda N, Fleeman R, Wang H, Ozawa A, Houghten RA, Shaw L. Li Y, et al. Among authors: houghten ra. Bioorg Med Chem. 2016 Nov 1;24(21):5633-5638. doi: 10.1016/j.bmc.2016.09.027. Epub 2016 Sep 12. Bioorg Med Chem. 2016. PMID: 27663549 Free PMC article.

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