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A meta-analysis of gene expression signatures of blood pressure and hypertension.
Huan T, Esko T, Peters MJ, Pilling LC, Schramm K, Schurmann C, Chen BH, Liu C, Joehanes R, Johnson AD, Yao C, Ying SX, Courchesne P, Milani L, Raghavachari N, Wang R, Liu P, Reinmaa E, Dehghan A, Hofman A, Uitterlinden AG, Hernandez DG, Bandinelli S, Singleton A, Melzer D, Metspalu A, Carstensen M, Grallert H, Herder C, Meitinger T, Peters A, Roden M, Waldenberger M, Dörr M, Felix SB, Zeller T; International Consortium for Blood Pressure GWAS (ICBP); Vasan R, O'Donnell CJ, Munson PJ, Yang X, Prokisch H, Völker U, van Meurs JB, Ferrucci L, Levy D. Huan T, et al. Among authors: yang x. PLoS Genet. 2015 Mar 18;11(3):e1005035. doi: 10.1371/journal.pgen.1005035. eCollection 2015 Mar. PLoS Genet. 2015. PMID: 25785607 Free PMC article.
Mapping the genetic architecture of gene expression in human liver.
Schadt EE, Molony C, Chudin E, Hao K, Yang X, Lum PY, Kasarskis A, Zhang B, Wang S, Suver C, Zhu J, Millstein J, Sieberts S, Lamb J, GuhaThakurta D, Derry J, Storey JD, Avila-Campillo I, Kruger MJ, Johnson JM, Rohl CA, van Nas A, Mehrabian M, Drake TA, Lusis AJ, Smith RC, Guengerich FP, Strom SC, Schuetz E, Rushmore TH, Ulrich R. Schadt EE, et al. Among authors: yang x. PLoS Biol. 2008 May 6;6(5):e107. doi: 10.1371/journal.pbio.0060107. PLoS Biol. 2008. PMID: 18462017 Free PMC article.
Liver and adipose expression associated SNPs are enriched for association to type 2 diabetes.
Zhong H, Beaulaurier J, Lum PY, Molony C, Yang X, Macneil DJ, Weingarth DT, Zhang B, Greenawalt D, Dobrin R, Hao K, Woo S, Fabre-Suver C, Qian S, Tota MR, Keller MP, Kendziorski CM, Yandell BS, Castro V, Attie AD, Kaplan LM, Schadt EE. Zhong H, et al. Among authors: yang x. PLoS Genet. 2010 May 6;6(5):e1000932. doi: 10.1371/journal.pgen.1000932. PLoS Genet. 2010. PMID: 20463879 Free PMC article.
Integrative analysis of a cross-loci regulation network identifies App as a gene regulating insulin secretion from pancreatic islets.
Tu Z, Keller MP, Zhang C, Rabaglia ME, Greenawalt DM, Yang X, Wang IM, Dai H, Bruss MD, Lum PY, Zhou YP, Kemp DM, Kendziorski C, Yandell BS, Attie AD, Schadt EE, Zhu J. Tu Z, et al. Among authors: yang x. PLoS Genet. 2012;8(12):e1003107. doi: 10.1371/journal.pgen.1003107. Epub 2012 Dec 6. PLoS Genet. 2012. PMID: 23236292 Free PMC article.
A systems biology framework identifies molecular underpinnings of coronary heart disease.
Huan T, Zhang B, Wang Z, Joehanes R, Zhu J, Johnson AD, Ying S, Munson PJ, Raghavachari N, Wang R, Liu P, Courchesne P, Hwang SJ, Assimes TL, McPherson R, Samani NJ, Schunkert H; Coronary ARteryDIsease Genome wide Replication and Meta-analysis (CARDIoGRAM) Consortium, International Consortium for Blood Pressure GWAS (ICBP); Meng Q, Suver C, O'Donnell CJ, Derry J, Yang X, Levy D. Huan T, et al. Among authors: yang x. Arterioscler Thromb Vasc Biol. 2013 Jun;33(6):1427-34. doi: 10.1161/ATVBAHA.112.300112. Epub 2013 Mar 28. Arterioscler Thromb Vasc Biol. 2013. PMID: 23539213 Free PMC article.
Integrative genomics reveals novel molecular pathways and gene networks for coronary artery disease.
Mäkinen VP, Civelek M, Meng Q, Zhang B, Zhu J, Levian C, Huan T, Segrè AV, Ghosh S, Vivar J, Nikpay M, Stewart AF, Nelson CP, Willenborg C, Erdmann J, Blakenberg S, O'Donnell CJ, März W, Laaksonen R, Epstein SE, Kathiresan S, Shah SH, Hazen SL, Reilly MP; Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Consortium; Lusis AJ, Samani NJ, Schunkert H, Quertermous T, McPherson R, Yang X, Assimes TL. Mäkinen VP, et al. Among authors: yang x. PLoS Genet. 2014 Jul 17;10(7):e1004502. doi: 10.1371/journal.pgen.1004502. eCollection 2014 Jul. PLoS Genet. 2014. PMID: 25033284 Free PMC article.
Common dysregulation network in the human prefrontal cortex underlies two neurodegenerative diseases.
Narayanan M, Huynh JL, Wang K, Yang X, Yoo S, McElwee J, Zhang B, Zhang C, Lamb JR, Xie T, Suver C, Molony C, Melquist S, Johnson AD, Fan G, Stone DJ, Schadt EE, Casaccia P, Emilsson V, Zhu J. Narayanan M, et al. Among authors: yang x. Mol Syst Biol. 2014 Jul 30;10(7):743. doi: 10.15252/msb.20145304. Mol Syst Biol. 2014. PMID: 25080494 Free PMC article.
Dissecting the roles of microRNAs in coronary heart disease via integrative genomic analyses.
Huan T, Rong J, Tanriverdi K, Meng Q, Bhattacharya A, McManus DD, Joehanes R, Assimes TL, McPherson R, Samani NJ, Erdmann J, Schunkert H, Courchesne P, Munson PJ, Johnson AD, O'Donnell CJ, Zhang B, Larson MG, Freedman JE, Levy D, Yang X. Huan T, et al. Among authors: yang x. Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):1011-21. doi: 10.1161/ATVBAHA.114.305176. Epub 2015 Feb 5. Arterioscler Thromb Vasc Biol. 2015. PMID: 25657313 Free PMC article.
Integrative network analysis reveals molecular mechanisms of blood pressure regulation.
Huan T, Meng Q, Saleh MA, Norlander AE, Joehanes R, Zhu J, Chen BH, Zhang B, Johnson AD, Ying S, Courchesne P, Raghavachari N, Wang R, Liu P; International Consortium for Blood Pressure GWAS (ICBP); O'Donnell CJ, Vasan R, Munson PJ, Madhur MS, Harrison DG, Yang X, Levy D. Huan T, et al. Among authors: yang x. Mol Syst Biol. 2015 Apr 16;11(1):799. doi: 10.15252/msb.20145399. Mol Syst Biol. 2015. PMID: 25882670 Free PMC article.
Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci.
Sazonova O, Zhao Y, Nürnberg S, Miller C, Pjanic M, Castano VG, Kim JB, Salfati EL, Kundaje AB, Bejerano G, Assimes T, Yang X, Quertermous T. Sazonova O, et al. Among authors: yang x. PLoS Genet. 2015 May 28;11(5):e1005202. doi: 10.1371/journal.pgen.1005202. eCollection 2015 May. PLoS Genet. 2015. PMID: 26020271 Free PMC article.
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