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Phenotype specific analyses reveal distinct regulatory mechanism for chronically activated p53.
Kirschner K, Samarajiwa SA, Cairns JM, Menon S, Pérez-Mancera PA, Tomimatsu K, Bermejo-Rodriguez C, Ito Y, Chandra T, Narita M, Lyons SK, Lynch AG, Kimura H, Ohbayashi T, Tavaré S, Narita M. Kirschner K, et al. PLoS Genet. 2015 Mar 19;11(3):e1005053. doi: 10.1371/journal.pgen.1005053. eCollection 2015 Mar. PLoS Genet. 2015. PMID: 25790137 Free PMC article.
Autophagy mediates the mitotic senescence transition.
Young AR, Narita M, Ferreira M, Kirschner K, Sadaie M, Darot JF, Tavaré S, Arakawa S, Shimizu S, Watt FM, Narita M. Young AR, et al. Among authors: kirschner k. Genes Dev. 2009 Apr 1;23(7):798-803. doi: 10.1101/gad.519709. Epub 2009 Mar 11. Genes Dev. 2009. PMID: 19279323 Free PMC article.
Independence of repressive histone marks and chromatin compaction during senescent heterochromatic layer formation.
Chandra T, Kirschner K, Thuret JY, Pope BD, Ryba T, Newman S, Ahmed K, Samarajiwa SA, Salama R, Carroll T, Stark R, Janky R, Narita M, Xue L, Chicas A, Nũnez S, Janknecht R, Hayashi-Takanaka Y, Wilson MD, Marshall A, Odom DT, Babu MM, Bazett-Jones DP, Tavaré S, Edwards PA, Lowe SW, Kimura H, Gilbert DM, Narita M. Chandra T, et al. Among authors: kirschner k. Mol Cell. 2012 Jul 27;47(2):203-14. doi: 10.1016/j.molcel.2012.06.010. Epub 2012 Jul 12. Mol Cell. 2012. PMID: 22795131 Free PMC article.
Latent regulatory potential of human-specific repetitive elements.
Ward MC, Wilson MD, Barbosa-Morais NL, Schmidt D, Stark R, Pan Q, Schwalie PC, Menon S, Lukk M, Watt S, Thybert D, Kutter C, Kirschner K, Flicek P, Blencowe BJ, Odom DT. Ward MC, et al. Among authors: kirschner k. Mol Cell. 2013 Jan 24;49(2):262-72. doi: 10.1016/j.molcel.2012.11.013. Epub 2012 Dec 13. Mol Cell. 2013. PMID: 23246434 Free PMC article.
Chromosome organisation during ageing and senescence.
Chandra T, Kirschner K. Chandra T, et al. Among authors: kirschner k. Curr Opin Cell Biol. 2016 Jun;40:161-167. doi: 10.1016/j.ceb.2016.03.020. Epub 2016 Apr 19. Curr Opin Cell Biol. 2016. PMID: 27101466 Free article. Review.
Experimental design for single-cell RNA sequencing.
Baran-Gale J, Chandra T, Kirschner K. Baran-Gale J, et al. Among authors: kirschner k. Brief Funct Genomics. 2018 Jul 1;17(4):233-239. doi: 10.1093/bfgp/elx035. Brief Funct Genomics. 2018. PMID: 29126257 Free PMC article. Review.
Functional heterogeneity in senescence.
Kirschner K, Rattanavirotkul N, Quince MF, Chandra T. Kirschner K, et al. Biochem Soc Trans. 2020 Jun 30;48(3):765-773. doi: 10.1042/BST20190109. Biochem Soc Trans. 2020. PMID: 32369550 Free PMC article. Review.
Clonality in haematopoietic stem cell ageing.
Terradas-Terradas M, Robertson NA, Chandra T, Kirschner K. Terradas-Terradas M, et al. Among authors: kirschner k. Mech Ageing Dev. 2020 Jul;189:111279. doi: 10.1016/j.mad.2020.111279. Epub 2020 Jun 8. Mech Ageing Dev. 2020. PMID: 32526214 Free PMC article. Review.
Induction and transmission of oncogene-induced senescence.
Rattanavirotkul N, Kirschner K, Chandra T. Rattanavirotkul N, et al. Among authors: kirschner k. Cell Mol Life Sci. 2021 Feb;78(3):843-852. doi: 10.1007/s00018-020-03638-0. Epub 2020 Sep 16. Cell Mol Life Sci. 2021. PMID: 32936311 Free PMC article. Review.
319 results