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Biotechnology. A prudent path forward for genomic engineering and germline gene modification.
Baltimore D, Berg P, Botchan M, Carroll D, Charo RA, Church G, Corn JE, Daley GQ, Doudna JA, Fenner M, Greely HT, Jinek M, Martin GS, Penhoet E, Puck J, Sternberg SH, Weissman JS, Yamamoto KR. Baltimore D, et al. Among authors: sternberg sh. Science. 2015 Apr 3;348(6230):36-8. doi: 10.1126/science.aab1028. Epub 2015 Mar 19. Science. 2015. PMID: 25791083 Free PMC article.
Substrate-specific kinetics of Dicer-catalyzed RNA processing.
Chakravarthy S, Sternberg SH, Kellenberger CA, Doudna JA. Chakravarthy S, et al. Among authors: sternberg sh. J Mol Biol. 2010 Dec 3;404(3):392-402. doi: 10.1016/j.jmb.2010.09.030. Epub 2010 Oct 13. J Mol Biol. 2010. PMID: 20932845 Free PMC article.
Structures of Cas9 endonucleases reveal RNA-mediated conformational activation.
Jinek M, Jiang F, Taylor DW, Sternberg SH, Kaya E, Ma E, Anders C, Hauer M, Zhou K, Lin S, Kaplan M, Iavarone AT, Charpentier E, Nogales E, Doudna JA. Jinek M, et al. Among authors: sternberg sh. Science. 2014 Mar 14;343(6176):1247997. doi: 10.1126/science.1247997. Epub 2014 Feb 6. Science. 2014. PMID: 24505130 Free PMC article.
Programmable RNA recognition and cleavage by CRISPR/Cas9.
O'Connell MR, Oakes BL, Sternberg SH, East-Seletsky A, Kaplan M, Doudna JA. O'Connell MR, et al. Among authors: sternberg sh. Nature. 2014 Dec 11;516(7530):263-6. doi: 10.1038/nature13769. Epub 2014 Sep 28. Nature. 2014. PMID: 25274302 Free PMC article.
Rational design of a split-Cas9 enzyme complex.
Wright AV, Sternberg SH, Taylor DW, Staahl BT, Bardales JA, Kornfeld JE, Doudna JA. Wright AV, et al. Among authors: sternberg sh. Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):2984-9. doi: 10.1073/pnas.1501698112. Epub 2015 Feb 23. Proc Natl Acad Sci U S A. 2015. PMID: 25713377 Free PMC article.
49 results