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Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival.
Ramos FJ, Chen SC, Garelick MG, Dai DF, Liao CY, Schreiber KH, MacKay VL, An EH, Strong R, Ladiges WC, Rabinovitch PS, Kaeberlein M, Kennedy BK. Ramos FJ, et al. Among authors: mackay vl. Sci Transl Med. 2012 Jul 25;4(144):144ra103. doi: 10.1126/scitranslmed.3003802. Sci Transl Med. 2012. PMID: 22837538 Free PMC article.
Translate this ... during dietary restriction.
Kennedy BK, Mackay VL. Kennedy BK, et al. Among authors: mackay vl. Cell Metab. 2009 Oct;10(4):247-8. doi: 10.1016/j.cmet.2009.09.004. Cell Metab. 2009. PMID: 19808017 Free article.
The eIF2-alpha kinase HRI is a novel therapeutic target in multiple myeloma.
Burwick N, Zhang MY, de la Puente P, Azab AK, Hyun TS, Ruiz-Gutierrez M, Sanchez-Bonilla M, Nakamura T, Delrow JJ, MacKay VL, Shimamura A. Burwick N, et al. Among authors: mackay vl. Leuk Res. 2017 Apr;55:23-32. doi: 10.1016/j.leukres.2017.01.007. Epub 2017 Jan 12. Leuk Res. 2017. PMID: 28119225 Free PMC article.
Ribosome deficiency protects against ER stress in Saccharomyces cerevisiae.
Steffen KK, McCormick MA, Pham KM, MacKay VL, Delaney JR, Murakami CJ, Kaeberlein M, Kennedy BK. Steffen KK, et al. Among authors: mackay vl. Genetics. 2012 May;191(1):107-18. doi: 10.1534/genetics.111.136549. Epub 2012 Feb 29. Genetics. 2012. PMID: 22377630 Free PMC article.
The ribosomal protein Rpl22 controls ribosome composition by directly repressing expression of its own paralog, Rpl22l1.
O'Leary MN, Schreiber KH, Zhang Y, Duc AC, Rao S, Hale JS, Academia EC, Shah SR, Morton JF, Holstein CA, Martin DB, Kaeberlein M, Ladiges WC, Fink PJ, Mackay VL, Wiest DL, Kennedy BK. O'Leary MN, et al. Among authors: mackay vl. PLoS Genet. 2013;9(8):e1003708. doi: 10.1371/journal.pgen.1003708. Epub 2013 Aug 22. PLoS Genet. 2013. PMID: 23990801 Free PMC article.
42 results