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The study to understand the genetics of the acute response to metformin and glipizide in humans (SUGAR-MGH): design of a pharmacogenetic resource for type 2 diabetes.
Walford GA, Colomo N, Todd JN, Billings LK, Fernandez M, Chamarthi B, Warner AS, Davis J, Littleton KR, Hernandez AM, Fanelli RR, Lanier A, Barbato C, Ackerman RJ, Khan SQ, Bui R, Garber L, Stolerman ES, Moore AF, Huang C, Kaur V, Harden M, Taylor A, Chen L, Manning AK, Huang P, Wexler D, McCarthy RM, Lo J, Thomas MK, Grant RW, Goldfine A, Hudson MS, Florez JC. Walford GA, et al. Among authors: florez jc. PLoS One. 2015 Mar 26;10(3):e0121553. doi: 10.1371/journal.pone.0121553. eCollection 2015. PLoS One. 2015. PMID: 25812009 Free PMC article. Clinical Trial.
Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals.
Saxena R, Gianniny L, Burtt NP, Lyssenko V, Giuducci C, Sjögren M, Florez JC, Almgren P, Isomaa B, Orho-Melander M, Lindblad U, Daly MJ, Tuomi T, Hirschhorn JN, Ardlie KG, Groop LC, Altshuler D. Saxena R, et al. Among authors: florez jc. Diabetes. 2006 Oct;55(10):2890-5. doi: 10.2337/db06-0381. Diabetes. 2006. PMID: 17003358
Effects of the type 2 diabetes-associated PPARG P12A polymorphism on progression to diabetes and response to troglitazone.
Florez JC, Jablonski KA, Sun MW, Bayley N, Kahn SE, Shamoon H, Hamman RF, Knowler WC, Nathan DM, Altshuler D; Diabetes Prevention Program Research Group. Florez JC, et al. J Clin Endocrinol Metab. 2007 Apr;92(4):1502-9. doi: 10.1210/jc.2006-2275. Epub 2007 Jan 9. J Clin Endocrinol Metab. 2007. PMID: 17213274 Free PMC article. Clinical Trial.
The new type 2 diabetes gene TCF7L2.
Florez JC. Florez JC. Curr Opin Clin Nutr Metab Care. 2007 Jul;10(4):391-6. doi: 10.1097/MCO.0b013e3281e2c9be. Curr Opin Clin Nutr Metab Care. 2007. PMID: 17563454 Review.
432 results