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A genome-wide expression quantitative trait loci analysis of proprotein convertase subtilisin/kexin enzymes identifies a novel regulatory gene variant for FURIN expression and blood pressure.
Turpeinen H, Seppälä I, Lyytikäinen LP, Raitoharju E, Hutri-Kähönen N, Levula M, Oksala N, Waldenberger M, Klopp N, Illig T, Mononen N, Laaksonen R, Raitakari O, Kähönen M, Lehtimäki T, Pesu M. Turpeinen H, et al. Among authors: levula m. Hum Genet. 2015 Jun;134(6):627-36. doi: 10.1007/s00439-015-1546-5. Epub 2015 Mar 27. Hum Genet. 2015. PMID: 25813623 Clinical Trial.
Proprotein convertases in human atherosclerotic plaques: the overexpression of FURIN and its substrate cytokines BAFF and APRIL.
Turpeinen H, Raitoharju E, Oksanen A, Oksala N, Levula M, Lyytikäinen LP, Järvinen O, Creemers JW, Kähönen M, Laaksonen R, Pelto-Huikko M, Lehtimäki T, Pesu M. Turpeinen H, et al. Among authors: levula m. Atherosclerosis. 2011 Dec;219(2):799-806. doi: 10.1016/j.atherosclerosis.2011.08.011. Epub 2011 Aug 22. Atherosclerosis. 2011. PMID: 21889147
Common variation in the ADAM8 gene affects serum sADAM8 concentrations and the risk of myocardial infarction in two independent cohorts.
Raitoharju E, Seppälä I, Levula M, Kuukasjärvi P, Laurikka J, Nikus K, Huovila AP, Oksala N, Klopp N, Illig T, Laaksonen R, Karhunen PJ, Viik J, Lehtinen R, Pelto-Huikko M, Tarkka M, Kähönen M, Lehtimäki T. Raitoharju E, et al. Among authors: levula m. Atherosclerosis. 2011 Sep;218(1):127-33. doi: 10.1016/j.atherosclerosis.2011.05.005. Epub 2011 May 13. Atherosclerosis. 2011. PMID: 21640993
A comparison of the accuracy of Illumina HumanHT-12 v3 Expression BeadChip and TaqMan qRT-PCR gene expression results in patient samples from the Tampere Vascular Study.
Raitoharju E, Seppälä I, Lyytikäinen LP, Levula M, Oksala N, Klopp N, Illig T, Laaksonen R, Kähönen M, Lehtimäki T. Raitoharju E, et al. Among authors: levula m. Atherosclerosis. 2013 Jan;226(1):149-52. doi: 10.1016/j.atherosclerosis.2012.10.078. Epub 2012 Nov 12. Atherosclerosis. 2013. PMID: 23177970
Association of neuroimmune guidance cue netrin-1 and its chemorepulsive receptor UNC5B with atherosclerotic plaque expression signatures and stability in human(s): Tampere Vascular Study (TVS).
Oksala N, Pärssinen J, Seppälä I, Raitoharju E, Kholova I, Hernesniemi J, Lyytikäinen LP, Levula M, Mäkelä KM, Sioris T, Kähönen M, Laaksonen R, Hytönen V, Lehtimäki T. Oksala N, et al. Among authors: levula m. Circ Cardiovasc Genet. 2013 Dec;6(6):579-87. doi: 10.1161/CIRCGENETICS.113.000141. Epub 2013 Oct 11. Circ Cardiovasc Genet. 2013. PMID: 24122613
ADAM8 and its single nucleotide polymorphism 2662 T/G are associated with advanced atherosclerosis and fatal myocardial infarction: Tampere vascular study.
Levula M, Airla N, Oksala N, Hernesniemi JA, Pelto-Huikko M, Salenius JP, Zeitlin R, Järvinen O, Huovila AP, Nikkari ST, Jaakkola O, Ilveskoski E, Mikkelsson J, Perola M, Laaksonen R, Kytömäki L, Soini JT, Kähönen M, Parkkinen J, Karhunen PJ, Lehtimäki T. Levula M, et al. Ann Med. 2009;41(7):497-507. doi: 10.1080/07853890903025945. Ann Med. 2009. PMID: 19575316
Upstream Transcription Factor 1 (USF1) allelic variants regulate lipoprotein metabolism in women and USF1 expression in atherosclerotic plaque.
Fan YM, Hernesniemi J, Oksala N, Levula M, Raitoharju E, Collings A, Hutri-Kähönen N, Juonala M, Marniemi J, Lyytikäinen LP, Seppälä I, Mennander A, Tarkka M, Kangas AJ, Soininen P, Salenius JP, Klopp N, Illig T, Laitinen T, Ala-Korpela M, Laaksonen R, Viikari J, Kähönen M, Raitakari OT, Lehtimäki T. Fan YM, et al. Among authors: levula m. Sci Rep. 2014 Apr 11;4:4650. doi: 10.1038/srep04650. Sci Rep. 2014. PMID: 24722012 Free PMC article.
Kindlin 3 (FERMT3) is associated with unstable atherosclerotic plaques, anti-inflammatory type II macrophages and upregulation of beta-2 integrins in all major arterial beds.
Oksala N, Pärssinen J, Seppälä I, Klopp N, Illig T, Laaksonen R, Levula M, Raitoharju E, Kholova I, Sioris T, Kähönen M, Lehtimäki T, Hytönen VP. Oksala N, et al. Among authors: levula m. Atherosclerosis. 2015 Sep;242(1):145-54. doi: 10.1016/j.atherosclerosis.2015.06.058. Epub 2015 Jul 13. Atherosclerosis. 2015. PMID: 26188538
Differentially expressed genes and canonical pathway expression in human atherosclerotic plaques - Tampere Vascular Study.
Sulkava M, Raitoharju E, Levula M, Seppälä I, Lyytikäinen LP, Mennander A, Järvinen O, Zeitlin R, Salenius JP, Illig T, Klopp N, Mononen N, Laaksonen R, Kähönen M, Oksala N, Lehtimäki T. Sulkava M, et al. Among authors: levula m. Sci Rep. 2017 Jan 27;7:41483. doi: 10.1038/srep41483. Sci Rep. 2017. PMID: 28128285 Free PMC article.
25 results