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Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome.
Macia L, Tan J, Vieira AT, Leach K, Stanley D, Luong S, Maruya M, Ian McKenzie C, Hijikata A, Wong C, Binge L, Thorburn AN, Chevalier N, Ang C, Marino E, Robert R, Offermanns S, Teixeira MM, Moore RJ, Flavell RA, Fagarasan S, Mackay CR. Macia L, et al. Among authors: leach k. Nat Commun. 2015 Apr 1;6:6734. doi: 10.1038/ncomms7734. Nat Commun. 2015. PMID: 25828455 Free article.
Crystal structures of the M1 and M4 muscarinic acetylcholine receptors.
Thal DM, Sun B, Feng D, Nawaratne V, Leach K, Felder CC, Bures MG, Evans DA, Weis WI, Bachhawat P, Kobilka TS, Sexton PM, Kobilka BK, Christopoulos A. Thal DM, et al. Among authors: leach k. Nature. 2016 Mar 17;531(7594):335-40. doi: 10.1038/nature17188. Epub 2016 Mar 9. Nature. 2016. PMID: 26958838 Free PMC article.
Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation.
Deganutti G, Liang YL, Zhang X, Khoshouei M, Clydesdale L, Belousoff MJ, Venugopal H, Truong TT, Glukhova A, Keller AN, Gregory KJ, Leach K, Christopoulos A, Danev R, Reynolds CA, Zhao P, Sexton PM, Wootten D. Deganutti G, et al. Among authors: leach k. Nat Commun. 2022 Jan 10;13(1):92. doi: 10.1038/s41467-021-27760-0. Nat Commun. 2022. PMID: 35013280 Free PMC article.
Allosteric modulation of G protein-coupled receptors.
May LT, Leach K, Sexton PM, Christopoulos A. May LT, et al. Among authors: leach k. Annu Rev Pharmacol Toxicol. 2007;47:1-51. doi: 10.1146/annurev.pharmtox.47.120505.105159. Annu Rev Pharmacol Toxicol. 2007. PMID: 17009927 Review.
THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein-coupled receptors.
Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. Alexander SPH, et al. Br J Pharmacol. 2019 Dec;176 Suppl 1(Suppl 1):S21-S141. doi: 10.1111/bph.14748. Br J Pharmacol. 2019. PMID: 31710717 Free PMC article. Review.
Murine GPRC6A Mediates Cellular Responses to L-Amino Acids, but Not Osteocalcin Variants.
Rueda P, Harley E, Lu Y, Stewart GD, Fabb S, Diepenhorst N, Cremers B, Rouillon MH, Wehrle I, Geant A, Lamarche G, Leach K, Charman WN, Christopoulos A, Summers RJ, Sexton PM, Langmead CJ. Rueda P, et al. Among authors: leach k. PLoS One. 2016 Jan 19;11(1):e0146846. doi: 10.1371/journal.pone.0146846. eCollection 2016. PLoS One. 2016. PMID: 26785252 Free PMC article.
321 results