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TDP-43 regulates the alternative splicing of hnRNP A1 to yield an aggregation-prone variant in amyotrophic lateral sclerosis.
Deshaies JE, Shkreta L, Moszczynski AJ, Sidibé H, Semmler S, Fouillen A, Bennett ER, Bekenstein U, Destroismaisons L, Toutant J, Delmotte Q, Volkening K, Stabile S, Aulas A, Khalfallah Y, Soreq H, Nanci A, Strong MJ, Chabot B, Vande Velde C. Deshaies JE, et al. Among authors: destroismaisons l. Brain. 2018 May 1;141(5):1320-1333. doi: 10.1093/brain/awy062. Brain. 2018. PMID: 29562314 Free PMC article.
ALS-linked misfolded SOD1 species have divergent impacts on mitochondria.
Pickles S, Semmler S, Broom HR, Destroismaisons L, Legroux L, Arbour N, Meiering E, Cashman NR, Vande Velde C. Pickles S, et al. Among authors: destroismaisons l. Acta Neuropathol Commun. 2016 Apr 27;4(1):43. doi: 10.1186/s40478-016-0313-8. Acta Neuropathol Commun. 2016. PMID: 27121871 Free PMC article.
TNF receptor-associated factor 6 interacts with ALS-linked misfolded superoxide dismutase 1 and promotes aggregation.
Semmler S, Gagné M, Garg P, Pickles SR, Baudouin C, Hamon-Keromen E, Destroismaisons L, Khalfallah Y, Chaineau M, Caron E, Bayne AN, Trempe JF, Cashman NR, Star AT, Haqqani AS, Durcan TM, Meiering EM, Robertson J, Grandvaux N, Plotkin SS, McBride HM, Vande Velde C. Semmler S, et al. Among authors: destroismaisons l. J Biol Chem. 2020 Mar 20;295(12):3808-3825. doi: 10.1074/jbc.RA119.011215. Epub 2020 Feb 6. J Biol Chem. 2020. PMID: 32029478 Free PMC article.
The human MSH5 (MutSHomolog 5) protein localizes to mitochondria and protects the mitochondrial genome from oxidative damage.
Bannwarth S, Figueroa A, Fragaki K, Destroismaisons L, Lacas-Gervais S, Lespinasse F, Vandenbos F, Pradelli LA, Ricci JE, Rötig A, Michiels JF, Vande Velde C, Paquis-Flucklinger V. Bannwarth S, et al. Among authors: destroismaisons l. Mitochondrion. 2012 Nov;12(6):654-65. doi: 10.1016/j.mito.2012.07.111. Epub 2012 Aug 11. Mitochondrion. 2012. PMID: 22917773
Mitochondrial damage revealed by immunoselection for ALS-linked misfolded SOD1.
Pickles S, Destroismaisons L, Peyrard SL, Cadot S, Rouleau GA, Brown RH Jr, Julien JP, Arbour N, Vande Velde C. Pickles S, et al. Among authors: destroismaisons l. Hum Mol Genet. 2013 Oct 1;22(19):3947-59. doi: 10.1093/hmg/ddt249. Epub 2013 Jun 4. Hum Mol Genet. 2013. PMID: 23736301 Free PMC article.
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