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A common sugar-nucleotide-mediated mechanism of inhibition of (glycosamino)glycan biosynthesis, as evidenced by 6F-GalNAc (Ac3).
van Wijk XM, Lawrence R, Thijssen VL, van den Broek SA, Troost R, van Scherpenzeel M, Naidu N, Oosterhof A, Griffioen AW, Lefeber DJ, van Delft FL, van Kuppevelt TH. van Wijk XM, et al. Among authors: lawrence r. FASEB J. 2015 Jul;29(7):2993-3002. doi: 10.1096/fj.14-264226. Epub 2015 Apr 13. FASEB J. 2015. PMID: 25868729 Free PMC article.
Interfering with UDP-GlcNAc metabolism and heparan sulfate expression using a sugar analogue reduces angiogenesis.
van Wijk XM, Thijssen VL, Lawrence R, van den Broek SA, Dona M, Naidu N, Oosterhof A, van de Westerlo EM, Kusters LJ, Khaled Y, Jokela TA, Nowak-Sliwinska P, Kremer H, Stringer SE, Griffioen AW, van Wijk E, van Delft FL, van Kuppevelt TH. van Wijk XM, et al. Among authors: lawrence r. ACS Chem Biol. 2013 Oct 18;8(10):2331-8. doi: 10.1021/cb4004332. Epub 2013 Sep 3. ACS Chem Biol. 2013. PMID: 23972127 Free PMC article.
Surfen, a small molecule antagonist of heparan sulfate.
Schuksz M, Fuster MM, Brown JR, Crawford BE, Ditto DP, Lawrence R, Glass CA, Wang L, Tor Y, Esko JD. Schuksz M, et al. Among authors: lawrence r. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13075-80. doi: 10.1073/pnas.0805862105. Epub 2008 Aug 25. Proc Natl Acad Sci U S A. 2008. PMID: 18725627 Free PMC article.
Glycan-based biomarkers for mucopolysaccharidoses.
Lawrence R, Brown JR, Lorey F, Dickson PI, Crawford BE, Esko JD. Lawrence R, et al. Mol Genet Metab. 2014 Feb;111(2):73-83. doi: 10.1016/j.ymgme.2013.07.016. Epub 2013 Jul 29. Mol Genet Metab. 2014. PMID: 23958290 Free PMC article. Review.
Secondary storage of dermatan sulfate in Sanfilippo disease.
Lamanna WC, Lawrence R, Sarrazin S, Esko JD. Lamanna WC, et al. Among authors: lawrence r. J Biol Chem. 2011 Mar 4;286(9):6955-62. doi: 10.1074/jbc.M110.192062. Epub 2010 Dec 30. J Biol Chem. 2011. PMID: 21193389 Free PMC article.
1,656 results