Maw G - Search Results

1

Discovery of a Selective TRPM8 Antagonist with Clinical Efficacy in Cold-Related Pain.

Andrews MD, Af Forselles K, Beaumont K, Galan SR, Glossop PA, Grenie M, Jessiman A, Kenyon AS, Lunn G, Maw G, Owen RM, Pryde DC, Roberts D, Tran TD. Andrews MD, et al. Among authors: maw g. ACS Med Chem Lett. 2015 Jan 30;6(4):419-24. doi: 10.1021/ml500479v. eCollection 2015 Apr 9. ACS Med Chem Lett. 2015. PMID: 25893043 Free PMC article.

2

Novel selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder. Synthesis and activity of functionalized glutaramides.

Pryde DC, Maw GN, Planken S, Platts MY, Sanderson V, Corless M, Stobie A, Barber CG, Russell R, Foster L, Barker L, Wayman C, Van Der Graaf P, Stacey P, Morren D, Kohl C, Beaumont K, Coggon S, Tute M. Pryde DC, et al. Among authors: maw gn. J Med Chem. 2006 Jul 13;49(14):4409-24. doi: 10.1021/jm060133g. J Med Chem. 2006. PMID: 16821800

3

Highly potent and selective zwitterionic agonists of the delta-opioid receptor. Part 1.

Middleton DS, Maw GN, Challenger C, Jessiman A, Johnson PS, Million WA, Nichols CL, Price JA, Trevethick M. Middleton DS, et al. Bioorg Med Chem Lett. 2006 Feb 15;16(4):905-10. doi: 10.1016/j.bmcl.2005.10.102. Epub 2005 Nov 15. Bioorg Med Chem Lett. 2006. PMID: 16290934

4

A novel series of potent and selective PDE5 inhibitors with potential for high and dose-independent oral bioavailability.

Allerton CM, Barber CG, Beaumont KC, Brown DG, Cole SM, Ellis D, Lane CA, Maw GN, Mount NM, Rawson DJ, Robinson CM, Street SD, Summerhill NW. Allerton CM, et al. Among authors: maw gn. J Med Chem. 2006 Jun 15;49(12):3581-94. doi: 10.1021/jm060113e. J Med Chem. 2006. PMID: 16759100

5

Discovery and Optimization of Selective Nav1.8 Modulator Series That Demonstrate Efficacy in Preclinical Models of Pain.

Bagal SK, Bungay PJ, Denton SM, Gibson KR, Glossop MS, Hay TL, Kemp MI, Lane CA, Lewis ML, Maw GN, Million WA, Payne CE, Poinsard C, Rawson DJ, Stammen BL, Stevens EB, Thompson LR. Bagal SK, et al. Among authors: maw gn. ACS Med Chem Lett. 2015 Apr 29;6(6):650-4. doi: 10.1021/acsmedchemlett.5b00059. eCollection 2015 Jun 11. ACS Med Chem Lett. 2015. PMID: 26101568 Free PMC article.

6

The discovery of small molecule inhibitors of neutral endopeptidase. Structure-activity studies on functionalized glutaramides.

Maw GN, Stobie A, Planken S, Pryde DC, Sanderson V, Platts MY, Corless M, Stacey P, Wayman C, Van Der Graaf P, Kohl C, Coggon S, Beaumont K. Maw GN, et al. Chem Biol Drug Des. 2006 Jan;67(1):74-7. doi: 10.1111/j.1747-0285.2005.00320.x. Chem Biol Drug Des. 2006. PMID: 16492151

7

The discovery of UK-369003, a novel PDE5 inhibitor with the potential for oral bioavailability and dose-proportional pharmacokinetics.

Rawson DJ, Ballard S, Barber C, Barker L, Beaumont K, Bunnage M, Cole S, Corless M, Denton S, Ellis D, Floc'h M, Foster L, Gosset J, Holmwood F, Lane C, Leahy D, Mathias J, Maw G, Million W, Poinsard C, Price J, Russel R, Street S, Watson L. Rawson DJ, et al. Among authors: maw g. Bioorg Med Chem. 2012 Jan 1;20(1):498-509. doi: 10.1016/j.bmc.2011.10.022. Epub 2011 Oct 24. Bioorg Med Chem. 2012. PMID: 22100260

8

2,4-Diaminopyridine delta-opioid receptor agonists and their associated hERG pharmacology.

Owen DR, Rodriguez-Lens M, Corless MD, Gaulier SM, Horne VA, Kinloch RA, Maw GN, Pearce DW, Rees H, Ringer TJ, Ryckmans T, Stammen BL. Owen DR, et al. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1702-6. doi: 10.1016/j.bmcl.2009.01.106. Epub 2009 Feb 5. Bioorg Med Chem Lett. 2009. PMID: 19231185

9

Structure-activity relationships of novel non-competitive mGluR1 antagonists: a potential treatment for chronic pain.

Owen DR, Dodd PG, Gayton S, Greener BS, Harbottle GW, Mantell SJ, Maw GN, Osborne SA, Rees H, Ringer TJ, Rodriguez-Lens M, Smith GF. Owen DR, et al. Among authors: maw gn. Bioorg Med Chem Lett. 2007 Jan 15;17(2):486-90. doi: 10.1016/j.bmcl.2006.10.015. Epub 2006 Oct 11. Bioorg Med Chem Lett. 2007. PMID: 17064898

10

Part 1: N-alkylated glycines as potent α2δ ligands.

Thompson LR, Blakemore DC, Brugier D, Bryans JS, Chu WL, Maw GN, Poinsard C, Rawson DJ, Warren AN. Thompson LR, et al. Among authors: maw gn. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3764-6. doi: 10.1016/j.bmcl.2011.04.045. Epub 2011 Apr 30. Bioorg Med Chem Lett. 2011. PMID: 21601457

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