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Page 1
Discovery of a Selective TRPM8 Antagonist with Clinical Efficacy in Cold-Related Pain.
Andrews MD, Af Forselles K, Beaumont K, Galan SR, Glossop PA, Grenie M, Jessiman A, Kenyon AS, Lunn G, Maw G, Owen RM, Pryde DC, Roberts D, Tran TD. Andrews MD, et al. Among authors: pryde dc. ACS Med Chem Lett. 2015 Jan 30;6(4):419-24. doi: 10.1021/ml500479v. eCollection 2015 Apr 9. ACS Med Chem Lett. 2015. PMID: 25893043 Free PMC article.
An imidazopiperidine series of CCR5 antagonists for the treatment of HIV: the discovery of N-{(1S)-1-(3-fluorophenyl)-3-[(3-endo)-3-(5-isobutyryl-2-methyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}acetamide (PF-232798).
Stupple PA, Batchelor DV, Corless M, Dorr PK, Ellis D, Fenwick DR, Galan SR, Jones RM, Mason HJ, Middleton DS, Perros M, Perruccio F, Platts MY, Pryde DC, Rodrigues D, Smith NN, Stephenson PT, Webster R, Westby M, Wood A. Stupple PA, et al. Among authors: pryde dc. J Med Chem. 2011 Jan 13;54(1):67-77. doi: 10.1021/jm100978n. Epub 2010 Dec 3. J Med Chem. 2011. PMID: 21128663
Ion channels as therapeutic targets: a drug discovery perspective.
Bagal SK, Brown AD, Cox PJ, Omoto K, Owen RM, Pryde DC, Sidders B, Skerratt SE, Stevens EB, Storer RI, Swain NA. Bagal SK, et al. Among authors: pryde dc. J Med Chem. 2013 Feb 14;56(3):593-624. doi: 10.1021/jm3011433. Epub 2012 Nov 29. J Med Chem. 2013. PMID: 23121096 Review.
Small, non-peptide C5a receptor antagonists: part 2.
Blagg J, Mowbray C, Pryde D, Salmon G, Fairman D, Schmid E, Beaumont K. Blagg J, et al. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5605-8. doi: 10.1016/j.bmcl.2008.08.101. Epub 2008 Aug 31. Bioorg Med Chem Lett. 2008. PMID: 18804369
Design and Identification of a Novel, Functionally Subtype Selective GABAA Positive Allosteric Modulator (PF-06372865).
Owen RM, Blakemore D, Cao L, Flanagan N, Fish R, Gibson KR, Gurrell R, Huh CW, Kammonen J, Mortimer-Cassen E, Nickolls SA, Omoto K, Owen D, Pike A, Pryde DC, Reynolds DS, Roeloffs R, Rose C, Stead C, Takeuchi M, Warmus JS, Watson C. Owen RM, et al. Among authors: pryde dc. J Med Chem. 2019 Jun 27;62(12):5773-5796. doi: 10.1021/acs.jmedchem.9b00322. Epub 2019 Apr 26. J Med Chem. 2019. PMID: 30964988
Novel selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder. Synthesis and activity of functionalized glutaramides.
Pryde DC, Maw GN, Planken S, Platts MY, Sanderson V, Corless M, Stobie A, Barber CG, Russell R, Foster L, Barker L, Wayman C, Van Der Graaf P, Stacey P, Morren D, Kohl C, Beaumont K, Coggon S, Tute M. Pryde DC, et al. J Med Chem. 2006 Jul 13;49(14):4409-24. doi: 10.1021/jm060133g. J Med Chem. 2006. PMID: 16821800
Small, non-peptide C5a receptor antagonists: part 1.
Blagg J, Mowbray C, Pryde DC, Salmon G, Schmid E, Fairman D, Beaumont K. Blagg J, et al. Among authors: pryde dc. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5601-4. doi: 10.1016/j.bmcl.2008.08.106. Epub 2008 Aug 31. Bioorg Med Chem Lett. 2008. PMID: 18809326
Non-benzimidazole containing inhibitors of respiratory syncytial virus.
Pryde DC, Tran TD, Gardner I, Bright H, Stupple P, Galan S, Alsop L, Watson L, Middleton DS, Dayal S, Platts M, Murray EJ, Parkinson T, Webster R. Pryde DC, et al. Bioorg Med Chem Lett. 2013 Feb 1;23(3):827-33. doi: 10.1016/j.bmcl.2012.11.062. Epub 2012 Nov 29. Bioorg Med Chem Lett. 2013. PMID: 23265891
55 results