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N-(1'-naphthyl)-3,4,5-trimethoxybenzohydrazide as microtubule destabilizer: Synthesis, cytotoxicity, inhibition of cell migration and in vivo activity against acute lymphoblastic leukemia.
Salum LB, Mascarello A, Canevarolo RR, Altei WF, Laranjeira AB, Neuenfeldt PD, Stumpf TR, Chiaradia-Delatorre LD, Vollmer LL, Daghestani HN, de Souza Melo CP, Silveira AB, Leal PC, Frederico MJ, do Nascimento LF, Santos AR, Andricopulo AD, Day BW, Yunes RA, Vogt A, Yunes JA, Nunes RJ. Salum LB, et al. Among authors: canevarolo rr. Eur J Med Chem. 2015;96:504-18. doi: 10.1016/j.ejmech.2015.02.041. Epub 2015 Feb 23. Eur J Med Chem. 2015. PMID: 25951294
IAP and HDAC inhibitors interact synergistically in myeloma cells through noncanonical NF-κB- and caspase-8-dependent mechanisms.
Zhou L, Zhang Y, Meads MB, Dai Y, Ning Y, Hu X, Li L, Sharma K, Nkwocha J, Parker R, Bui D, McCarter J, Kramer L, Purcell C, Sudalagunta PR, Canevarolo RR, Coelho Siqueira Silva MD, De Avila G, Alugubelli RR, Silva AS, Kmeiciak M, Ferreira-Gonzalez A, Shain KH, Grant S. Zhou L, et al. Among authors: canevarolo rr. Blood Adv. 2021 Oct 12;5(19):3776-3788. doi: 10.1182/bloodadvances.2020003597. Blood Adv. 2021. PMID: 34464977 Free PMC article.
Plasma cell dependence on histone/protein deacetylase 11 reveals a therapeutic target in multiple myeloma.
Mostofa A, Distler A, Meads MB, Sahakian E, Powers JJ, Achille A, Noyes D, Wright G, Fang B, Izumi V, Koomen J, Rampakrishnan R, Nguyen TP, De Avila G, Silva AS, Sudalagunta P, Canevarolo RR, Siqueira Silva MDC, Alugubelli RR, Dai HA, Kulkarni A, Dalton WS, Hampton OA, Welsh EA, Teer JK, Tungesvik A, Wright KL, Pinilla-Ibarz J, Sotomayor EM, Shain KH, Brayer J. Mostofa A, et al. Among authors: canevarolo rr. JCI Insight. 2021 Dec 22;6(24):e151713. doi: 10.1172/jci.insight.151713. JCI Insight. 2021. PMID: 34793338 Free PMC article.
A pharmacodynamic model of clinical synergy in multiple myeloma.
Sudalagunta P, Silva MC, Canevarolo RR, Alugubelli RR, DeAvila G, Tungesvik A, Perez L, Gatenby R, Gillies R, Baz R, Meads MB, Shain KH, Silva AS. Sudalagunta P, et al. Among authors: canevarolo rr. EBioMedicine. 2020 Apr;54:102716. doi: 10.1016/j.ebiom.2020.102716. Epub 2020 Apr 5. EBioMedicine. 2020. PMID: 32268267 Free PMC article.
CancerCellTracker: a brightfield time-lapse microscopy framework for cancer drug sensitivity estimation.
Jiang Q, Sudalagunta P, Silva MC, Canevarolo RR, Zhao X, Ahmed KT, Alugubelli RR, DeAvila G, Tungesvik A, Perez L, Gatenby RA, Gillies RJ, Baz R, Meads MB, Shain KH, Silva AS, Zhang W. Jiang Q, et al. Among authors: canevarolo rr. Bioinformatics. 2022 Aug 10;38(16):4002-4010. doi: 10.1093/bioinformatics/btac417. Bioinformatics. 2022. PMID: 35751591 Free PMC article.
Cytotoxic 3,4,5-trimethoxychalcones as mitotic arresters and cell migration inhibitors.
Salum LB, Altei WF, Chiaradia LD, Cordeiro MN, Canevarolo RR, Melo CP, Winter E, Mattei B, Daghestani HN, Santos-Silva MC, Creczynski-Pasa TB, Yunes RA, Yunes JA, Andricopulo AD, Day BW, Nunes RJ, Vogt A. Salum LB, et al. Among authors: canevarolo rr. Eur J Med Chem. 2013 May;63:501-10. doi: 10.1016/j.ejmech.2013.02.037. Epub 2013 Mar 6. Eur J Med Chem. 2013. PMID: 23524161 Free PMC article.
Structural Basis of Colchicine-Site targeting Acylhydrazones active against Multidrug-Resistant Acute Lymphoblastic Leukemia.
Cury NM, Mühlethaler T, Laranjeira ABA, Canevarolo RR, Zenatti PP, Lucena-Agell D, Barasoain I, Song C, Sun D, Dovat S, Yunes RA, Prota AE, Steinmetz MO, Díaz JF, Yunes JA. Cury NM, et al. Among authors: canevarolo rr. iScience. 2019 Nov 22;21:95-109. doi: 10.1016/j.isci.2019.10.003. Epub 2019 Oct 2. iScience. 2019. PMID: 31655259 Free PMC article.
21 results