Dai Y - Search Results

1

Discovery of N-(4-(3-(2-aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine (AMG 900), a highly selective, orally bioavailable inhibitor of aurora kinases with activity against multidrug-resistant cancer cell lines.

Geuns-Meyer S, Cee VJ, Deak HL, Du B, Hodous BL, Nguyen HN, Olivieri PR, Schenkel LB, Vaida KR, Andrews P, Bak A, Be X, Beltran PJ, Bush TL, Chaves MK, Chung G, Dai Y, Eden P, Hanestad K, Huang L, Lin MH, Tang J, Ziegler B, Radinsky R, Kendall R, Patel VF, Payton M. Geuns-Meyer S, et al. Among authors: dai y. J Med Chem. 2015 Jul 9;58(13):5189-207. doi: 10.1021/acs.jmedchem.5b00183. Epub 2015 May 31. J Med Chem. 2015. PMID: 25970324

2

Design, synthesis and biological evaluation of pyrazolylaminoquinazoline derivatives as highly potent pan-fibroblast growth factor receptor inhibitors.

Fan J, Dai Y, Shao J, Peng X, Wang C, Cao S, Zhao B, Ai J, Geng M, Duan W. Fan J, et al. Among authors: dai y. Bioorg Med Chem Lett. 2016 Jun 1;26(11):2594-9. doi: 10.1016/j.bmcl.2016.04.028. Epub 2016 Apr 12. Bioorg Med Chem Lett. 2016. PMID: 27117427

3

Discovery of 3-(5'-Substituted)-Benzimidazole-5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazoles as Potent Fibroblast Growth Factor Receptor Inhibitors: Design, Synthesis, and Biological Evaluation.

Yan W, Wang X, Dai Y, Zhao B, Yang X, Fan J, Gao Y, Meng F, Wang Y, Luo C, Ai J, Geng M, Duan W. Yan W, et al. Among authors: dai y. J Med Chem. 2016 Jul 28;59(14):6690-708. doi: 10.1021/acs.jmedchem.6b00056. Epub 2016 Jul 6. J Med Chem. 2016. PMID: 27348537

4

Discovery of Potent Irreversible Pan-Fibroblast Growth Factor Receptor (FGFR) Inhibitors.

Wang Y, Li L, Fan J, Dai Y, Jiang A, Geng M, Ai J, Duan W. Wang Y, et al. Among authors: dai y. J Med Chem. 2018 Oct 25;61(20):9085-9104. doi: 10.1021/acs.jmedchem.7b01843. Epub 2018 Mar 16. J Med Chem. 2018. PMID: 29522671

5

Discovery and optimization of a series of 3-substituted indazole derivatives as multi-target kinase inhibitors for the treatment of lung squamous cell carcinoma.

Wang Q, Dai Y, Ji Y, Shi H, Guo Z, Chen D, Chen Y, Peng X, Gao Y, Wang X, Chen L, Jiang Y, Geng M, Shen J, Ai J, Xiong B. Wang Q, et al. Among authors: dai y. Eur J Med Chem. 2019 Feb 1;163:671-689. doi: 10.1016/j.ejmech.2018.12.015. Epub 2018 Dec 7. Eur J Med Chem. 2019. PMID: 30572178

6

Discovery of a Pyrimidinedione Derivative as a Potent and Orally Bioavailable Axl Inhibitor.

Zhang H, Peng X, Dai Y, Shao J, Ji Y, Sun Y, Liu B, Cheng X, Ai J, Duan W. Zhang H, et al. Among authors: dai y. J Med Chem. 2021 Apr 8;64(7):3956-3975. doi: 10.1021/acs.jmedchem.0c02093. Epub 2021 Mar 18. J Med Chem. 2021. PMID: 33733758

7

Discovery of Substituted 1H-Pyrazolo[3,4-b]pyridine Derivatives as Potent and Selective FGFR Kinase Inhibitors.

Zhao B, Li Y, Xu P, Dai Y, Luo C, Sun Y, Ai J, Geng M, Duan W. Zhao B, et al. Among authors: dai y. ACS Med Chem Lett. 2016 Apr 20;7(6):629-34. doi: 10.1021/acsmedchemlett.6b00066. eCollection 2016 Jun 9. ACS Med Chem Lett. 2016. PMID: 27326339 Free PMC article.

8

Optimization of 1H-indazol-3-amine derivatives as potent fibroblast growth factor receptor inhibitors.

Cui J, Peng X, Gao D, Dai Y, Ai J, Li Y. Cui J, et al. Among authors: dai y. Bioorg Med Chem Lett. 2017 Aug 15;27(16):3782-3786. doi: 10.1016/j.bmcl.2017.06.068. Epub 2017 Jun 27. Bioorg Med Chem Lett. 2017. PMID: 28687204

9

Design, synthesis and biological evaluation of a series of novel 2-benzamide-4-(6-oxy-N-methyl-1-naphthamide)-pyridine derivatives as potent fibroblast growth factor receptor (FGFR) inhibitors.

Wei M, Peng X, Xing L, Dai Y, Huang R, Geng M, Zhang A, Ai J, Song Z. Wei M, et al. Among authors: dai y. Eur J Med Chem. 2018 Jun 25;154:9-28. doi: 10.1016/j.ejmech.2018.05.005. Epub 2018 May 16. Eur J Med Chem. 2018. PMID: 29775937

10

Discovery of a potent tyrosine kinase AXL inhibitor bearing the 3-((2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)pyrazine core.

Wang Y, Xing L, Ji Y, Ye J, Dai Y, Gu W, Ai J, Song Z. Wang Y, et al. Among authors: dai y. Bioorg Med Chem Lett. 2019 Mar 15;29(6):836-838. doi: 10.1016/j.bmcl.2019.01.018. Epub 2019 Jan 21. Bioorg Med Chem Lett. 2019. PMID: 30685094

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