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The preclinical pharmacology of the high affinity anti-IL-6R Nanobody® ALX-0061 supports its clinical development in rheumatoid arthritis.
Van Roy M, Ververken C, Beirnaert E, Hoefman S, Kolkman J, Vierboom M, Breedveld E, 't Hart B, Poelmans S, Bontinck L, Hemeryck A, Jacobs S, Baumeister J, Ulrichts H. Van Roy M, et al. Arthritis Res Ther. 2015 May 20;17(1):135. doi: 10.1186/s13075-015-0651-0. Arthritis Res Ther. 2015. PMID: 25994180 Free PMC article.
Asymptomatic synovitis precedes clinically manifest arthritis.
Kraan MC, Versendaal H, Jonker M, Bresnihan B, Post WJ, t Hart BA, Breedveld FC, Tak PP. Kraan MC, et al. Arthritis Rheum. 1998 Aug;41(8):1481-8. doi: 10.1002/1529-0131(199808)41:8<1481::AID-ART19>3.0.CO;2-O. Arthritis Rheum. 1998. PMID: 9704648
Modeling human arthritic diseases in nonhuman primates.
Vierboom MP, Jonker M, Bontrop RE, 't Hart B. Vierboom MP, et al. Arthritis Res Ther. 2005;7(4):145-54. doi: 10.1186/ar1773. Epub 2005 Jun 9. Arthritis Res Ther. 2005. PMID: 15987497 Free PMC article. Review.
205 results