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Whole Genome Sequence of Multiple Myeloma-Prone C57BL/KaLwRij Mouse Strain Suggests the Origin of Disease Involves Multiple Cell Types.
Amend SR, Wilson WC, Chu L, Lu L, Liu P, Serie D, Su X, Xu Y, Wang D, Gramolini A, Wen XY, O'Neal J, Hurchla M, Vachon CM, Colditz G, Vij R, Weilbaecher KN, Tomasson MH. Amend SR, et al. Among authors: weilbaecher kn. PLoS One. 2015 May 28;10(5):e0127828. doi: 10.1371/journal.pone.0127828. eCollection 2015. PLoS One. 2015. PMID: 26020268 Free PMC article.
Platelet and osteoclast beta3 integrins are critical for bone metastasis.
Bakewell SJ, Nestor P, Prasad S, Tomasson MH, Dowland N, Mehrotra M, Scarborough R, Kanter J, Abe K, Phillips D, Weilbaecher KN. Bakewell SJ, et al. Among authors: weilbaecher kn. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14205-10. doi: 10.1073/pnas.2234372100. Epub 2003 Nov 11. Proc Natl Acad Sci U S A. 2003. PMID: 14612570 Free PMC article.
RelB is the NF-kappaB subunit downstream of NIK responsible for osteoclast differentiation.
Vaira S, Johnson T, Hirbe AC, Alhawagri M, Anwisye I, Sammut B, O'Neal J, Zou W, Weilbaecher KN, Faccio R, Novack DV. Vaira S, et al. Among authors: weilbaecher kn. Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3897-902. doi: 10.1073/pnas.0708576105. Epub 2008 Mar 5. Proc Natl Acad Sci U S A. 2008. PMID: 18322009 Free PMC article.
The ARF tumor suppressor regulates bone remodeling and osteosarcoma development in mice.
Rauch DA, Hurchla MA, Harding JC, Deng H, Shea LK, Eagleton MC, Niewiesk S, Lairmore MD, Piwnica-Worms D, Rosol TJ, Weber JD, Ratner L, Weilbaecher KN. Rauch DA, et al. Among authors: weilbaecher kn. PLoS One. 2010 Dec 30;5(12):e15755. doi: 10.1371/journal.pone.0015755. PLoS One. 2010. PMID: 21209895 Free PMC article.
Hedgehog signaling inhibition blocks growth of resistant tumors through effects on tumor microenvironment.
Heller E, Hurchla MA, Xiang J, Su X, Chen S, Schneider J, Joeng KS, Vidal M, Goldberg L, Deng H, Hornick MC, Prior JL, Piwnica-Worms D, Long F, Cagan R, Weilbaecher KN. Heller E, et al. Among authors: weilbaecher kn. Cancer Res. 2012 Feb 15;72(4):897-907. doi: 10.1158/0008-5472.CAN-11-2681. Epub 2011 Dec 20. Cancer Res. 2012. PMID: 22186138 Free PMC article.
The epoxyketone-based proteasome inhibitors carfilzomib and orally bioavailable oprozomib have anti-resorptive and bone-anabolic activity in addition to anti-myeloma effects.
Hurchla MA, Garcia-Gomez A, Hornick MC, Ocio EM, Li A, Blanco JF, Collins L, Kirk CJ, Piwnica-Worms D, Vij R, Tomasson MH, Pandiella A, San Miguel JF, Garayoa M, Weilbaecher KN. Hurchla MA, et al. Among authors: weilbaecher kn. Leukemia. 2013 Feb;27(2):430-40. doi: 10.1038/leu.2012.183. Epub 2012 Jul 5. Leukemia. 2013. PMID: 22763387 Free PMC article.
The ADP receptor P2RY12 regulates osteoclast function and pathologic bone remodeling.
Su X, Floyd DH, Hughes A, Xiang J, Schneider JG, Uluckan O, Heller E, Deng H, Zou W, Craft CS, Wu K, Hirbe AC, Grabowska D, Eagleton MC, Townsley S, Collins L, Piwnica-Worms D, Steinberg TH, Novack DV, Conley PB, Hurchla MA, Rogers M, Weilbaecher KN. Su X, et al. Among authors: weilbaecher kn. J Clin Invest. 2012 Oct;122(10):3579-92. doi: 10.1172/JCI38576. Epub 2012 Sep 17. J Clin Invest. 2012. PMID: 22996695 Free PMC article.
118 results