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Discovery of novel pyrazole-containing benzamides as potent RORγ inverse agonists.
Wang T, Banerjee D, Bohnert T, Chao J, Enyedy I, Fontenot J, Guertin K, Jones H, Lin EY, Marcotte D, Talreja T, Van Vloten K. Wang T, et al. Among authors: fontenot j. Bioorg Med Chem Lett. 2015 Aug 1;25(15):2985-90. doi: 10.1016/j.bmcl.2015.05.028. Epub 2015 May 22. Bioorg Med Chem Lett. 2015. PMID: 26048789
Discovery of biaryl carboxylamides as potent RORγ inverse agonists.
Chao J, Enyedy I, Van Vloten K, Marcotte D, Guertin K, Hutchings R, Powell N, Jones H, Bohnert T, Peng CC, Silvian L, Hong VS, Little K, Banerjee D, Peng L, Taveras A, Viney JL, Fontenot J. Chao J, et al. Among authors: fontenot j. Bioorg Med Chem Lett. 2015 Aug 1;25(15):2991-7. doi: 10.1016/j.bmcl.2015.05.026. Epub 2015 May 23. Bioorg Med Chem Lett. 2015. PMID: 26048806
Discovery of biaryls as RORγ inverse agonists by using structure-based design.
Enyedy IJ, Powell NA, Caravella J, van Vloten K, Chao J, Banerjee D, Marcotte D, Silvian L, McKenzie A, Hong VS, Fontenot JD. Enyedy IJ, et al. Among authors: fontenot jd. Bioorg Med Chem Lett. 2016 May 15;26(10):2459-2463. doi: 10.1016/j.bmcl.2016.03.109. Epub 2016 Apr 1. Bioorg Med Chem Lett. 2016. PMID: 27080181
Investigating small molecules to inhibit germinal center kinase-like kinase (GLK/MAP4K3) upstream of PKCθ phosphorylation: Potential therapy to modulate T cell dependent immunity.
May-Dracka TL, Arduini R, Bertolotti-Ciarlet A, Bhisetti G, Brickelmaier M, Cahir-McFarland E, Enyedy I, Fontenot JD, Hesson T, Little K, Lyssikatos J, Marcotte D, McKee T, Murugan P, Patterson T, Peng H, Rushe M, Silvian L, Spilker K, Wu P, Xin Z, Burkly LC. May-Dracka TL, et al. Among authors: fontenot jd. Bioorg Med Chem Lett. 2018 Jun 1;28(10):1964-1971. doi: 10.1016/j.bmcl.2018.03.032. Epub 2018 Mar 26. Bioorg Med Chem Lett. 2018. PMID: 29636220
In vivo maintenance of human regulatory T cells during CD25 blockade.
Huss DJ, Mehta DS, Sharma A, You X, Riester KA, Sheridan JP, Amaravadi LS, Elkins JS, Fontenot JD. Huss DJ, et al. Among authors: fontenot jd. J Immunol. 2015 Jan 1;194(1):84-92. doi: 10.4049/jimmunol.1402140. J Immunol. 2015. PMID: 25416807 Clinical Trial.
Harnessing regulatory T cells to establish immune tolerance.
Ho P, Cahir-McFarland E, Fontenot JD, Lodie T, Nada A, Tang Q, Turka LA, Bluestone JA. Ho P, et al. Among authors: fontenot jd. Sci Transl Med. 2024 Mar 13;16(738):eadm8859. doi: 10.1126/scitranslmed.adm8859. Epub 2024 Mar 13. Sci Transl Med. 2024. PMID: 38478632 Review.
247 results