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Discovery of [¹¹C]MK-8193 as a PET tracer to measure target engagement of phosphodiesterase 10A (PDE10A) inhibitors.
Cox CD, Hostetler ED, Flores BA, Evelhoch JL, Fan H, Gantert L, Holahan M, Eng W, Joshi A, McGaughey G, Meng X, Purcell M, Raheem IT, Riffel K, Yan Y, Renger JJ, Smith SM, Coleman PJ. Cox CD, et al. Among authors: meng x. Bioorg Med Chem Lett. 2015 Nov 1;25(21):4893-4898. doi: 10.1016/j.bmcl.2015.05.080. Epub 2015 Jun 1. Bioorg Med Chem Lett. 2015. PMID: 26077491
In Vivo Evaluation and Dosimetry Estimate for a High Affinity Affibody PET Tracer Targeting PD-L1.
Rubins DJ, Meng X, McQuade P, Klimas M, Getty K, Lin SA, Connolly BM, O'Malley SS, Haley H, Purcell M, Gantert L, Holahan M, Lindgren J, Eklund P, Ekblad C, Frejd FY, Hostetler ED, González Trotter DE, Evelhoch JL. Rubins DJ, et al. Among authors: meng x. Mol Imaging Biol. 2021 Apr;23(2):241-249. doi: 10.1007/s11307-020-01544-2. Epub 2020 Oct 23. Mol Imaging Biol. 2021. PMID: 33098025
In Vivo Imaging of the Programmed Death Ligand 1 by 18F PET.
González Trotter DE, Meng X, McQuade P, Rubins D, Klimas M, Zeng Z, Connolly BM, Miller PJ, O'Malley SS, Lin SA, Getty KL, Fayadat-Dilman L, Liang L, Wahlberg E, Widmark O, Ekblad C, Frejd FY, Hostetler ED, Evelhoch JL. González Trotter DE, et al. Among authors: meng x. J Nucl Med. 2017 Nov;58(11):1852-1857. doi: 10.2967/jnumed.117.191718. Epub 2017 Jun 6. J Nucl Med. 2017. PMID: 28588151 Free article.
MK-8719, a Novel and Selective O-GlcNAcase Inhibitor That Reduces the Formation of Pathological Tau and Ameliorates Neurodegeneration in a Mouse Model of Tauopathy.
Wang X, Li W, Marcus J, Pearson M, Song L, Smith K, Terracina G, Lee J, Hong KK, Lu SX, Hyde L, Chen SC, Kinsley D, Melchor JP, Rubins DJ, Meng X, Hostetler E, Sur C, Zhang L, Schachter JB, Hess JF, Selnick HG, Vocadlo DJ, McEachern EJ, Uslaner JM, Duffy JL, Smith SM. Wang X, et al. Among authors: meng x. J Pharmacol Exp Ther. 2020 Aug;374(2):252-263. doi: 10.1124/jpet.120.266122. Epub 2020 Jun 3. J Pharmacol Exp Ther. 2020. PMID: 32493725
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