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Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases.
ChemMedChem. 2015 Jul;10(7):1163-73. doi: 10.1002/cmdc.201500131. Epub 2015 Jun 17.
ChemMedChem. 2015.
PMID: 26083237
Free PMC article.
Potent and Selective Human Neutrophil Elastase Inhibitors with Novel Equatorial Ring Topology: in vivo Efficacy of the Polar Pyrimidopyridazine BAY-8040 in a Pulmonary Arterial Hypertension Rat Model.
von Nussbaum F, Li VM, Meibom D, Anlauf S, Bechem M, Delbeck M, Gerisch M, Harrenga A, Karthaus D, Lang D, Lustig K, Mittendorf J, Schäfer M, Schäfer S, Schamberger J.
von Nussbaum F, et al. Among authors: karthaus d.
ChemMedChem. 2016 Jan 19;11(2):199-206. doi: 10.1002/cmdc.201500269. Epub 2015 Sep 3.
ChemMedChem. 2016.
PMID: 26333652
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The novel selective PDE9 inhibitor BAY 73-6691 improves learning and memory in rodents.
van der Staay FJ, Rutten K, Bärfacker L, Devry J, Erb C, Heckroth H, Karthaus D, Tersteegen A, van Kampen M, Blokland A, Prickaerts J, Reymann KG, Schröder UH, Hendrix M.
van der Staay FJ, et al. Among authors: karthaus d.
Neuropharmacology. 2008 Oct;55(5):908-18. doi: 10.1016/j.neuropharm.2008.07.005. Epub 2008 Jul 12.
Neuropharmacology. 2008.
PMID: 18674549
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The Role of Changing Loop Conformations in Streptavidin Versions Engineered for High-affinity Binding of the Strep-tag II Peptide.
Schmidt TGM, Eichinger A, Schneider M, Bonet L, Carl U, Karthaus D, Theobald I, Skerra A.
Schmidt TGM, et al. Among authors: karthaus d.
J Mol Biol. 2021 Apr 30;433(9):166893. doi: 10.1016/j.jmb.2021.166893. Epub 2021 Feb 24.
J Mol Biol. 2021.
PMID: 33639211
Free article.
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Modeling of light-emitting diode wavefronts for the optimization of transmission holograms.
Karthaus D, Giehl M, Sandfuchs O, Sinzinger S.
Karthaus D, et al.
Appl Opt. 2017 Jun 20;56(18):5234-5241. doi: 10.1364/AO.56.005234.
Appl Opt. 2017.
PMID: 29047576
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The relationship between estrous behavioral score and time of ovulation in dairy cattle.
Van Eerdenburg FJ, Karthaus D, Taverne MA, Merics I, Szenci O.
Van Eerdenburg FJ, et al. Among authors: karthaus d.
J Dairy Sci. 2002 May;85(5):1150-6. doi: 10.3168/jds.s0022-0302(02)74177-5.
J Dairy Sci. 2002.
PMID: 12086050
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Treatment of life-threatening mediastinitis after resection of the esophagus by esophagostomy and subcutaneous preservation of the esophageal replacement.
de Graaf PW, Karthaus DJ Sr, Obertop H.
de Graaf PW, et al. Among authors: karthaus dj sr.
J Am Coll Surg. 1994 Jul;179(1):80-3.
J Am Coll Surg. 1994.
PMID: 8019732
No abstract available.
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[Acute intestinal hemorrhage and ECG-changes].
Schröder HJ, Karthaus D, Lübcke P.
Schröder HJ, et al. Among authors: karthaus d.
Ther Ggw. 1974 Sep;113(9):1476-85.
Ther Ggw. 1974.
PMID: 4548228
German.
No abstract available.
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