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Macrophages as mediators of tumor immunosurveillance.
Jaiswal S, Chao MP, Majeti R, Weissman IL. Jaiswal S, et al. Among authors: weissman il. Trends Immunol. 2010 Jun;31(6):212-9. doi: 10.1016/j.it.2010.04.001. Epub 2010 May 7. Trends Immunol. 2010. PMID: 20452821 Free PMC article. Review.
Anti-CD47 antibody synergizes with rituximab to promote phagocytosis and eradicate non-Hodgkin lymphoma.
Chao MP, Alizadeh AA, Tang C, Myklebust JH, Varghese B, Gill S, Jan M, Cha AC, Chan CK, Tan BT, Park CY, Zhao F, Kohrt HE, Malumbres R, Briones J, Gascoyne RD, Lossos IS, Levy R, Weissman IL, Majeti R. Chao MP, et al. Among authors: weissman il. Cell. 2010 Sep 3;142(5):699-713. doi: 10.1016/j.cell.2010.07.044. Cell. 2010. PMID: 20813259 Free PMC article.
Therapeutic antibody targeting of CD47 eliminates human acute lymphoblastic leukemia.
Chao MP, Alizadeh AA, Tang C, Jan M, Weissman-Tsukamoto R, Zhao F, Park CY, Weissman IL, Majeti R. Chao MP, et al. Among authors: weissman tsukamoto r, weissman il. Cancer Res. 2011 Feb 15;71(4):1374-84. doi: 10.1158/0008-5472.CAN-10-2238. Epub 2010 Dec 21. Cancer Res. 2011. PMID: 21177380 Free PMC article.
The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors.
Willingham SB, Volkmer JP, Gentles AJ, Sahoo D, Dalerba P, Mitra SS, Wang J, Contreras-Trujillo H, Martin R, Cohen JD, Lovelace P, Scheeren FA, Chao MP, Weiskopf K, Tang C, Volkmer AK, Naik TJ, Storm TA, Mosley AR, Edris B, Schmid SM, Sun CK, Chua MS, Murillo O, Rajendran P, Cha AC, Chin RK, Kim D, Adorno M, Raveh T, Tseng D, Jaiswal S, Enger PØ, Steinberg GK, Li G, So SK, Majeti R, Harsh GR, van de Rijn M, Teng NN, Sunwoo JB, Alizadeh AA, Clarke MF, Weissman IL. Willingham SB, et al. Among authors: weissman il. Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6662-7. doi: 10.1073/pnas.1121623109. Epub 2012 Mar 26. Proc Natl Acad Sci U S A. 2012. PMID: 22451913 Free PMC article.
Antibody therapy targeting the CD47 protein is effective in a model of aggressive metastatic leiomyosarcoma.
Edris B, Weiskopf K, Volkmer AK, Volkmer JP, Willingham SB, Contreras-Trujillo H, Liu J, Majeti R, West RB, Fletcher JA, Beck AH, Weissman IL, van de Rijn M. Edris B, et al. Among authors: weissman il. Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6656-61. doi: 10.1073/pnas.1121629109. Epub 2012 Mar 26. Proc Natl Acad Sci U S A. 2012. PMID: 22451919 Free PMC article.
896 results