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Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function.
Xiao S, Najafian N, Reddy J, Albin M, Zhu C, Jensen E, Imitola J, Korn T, Anderson AC, Zhang Z, Gutierrez C, Moll T, Sobel RA, Umetsu DT, Yagita H, Akiba H, Strom T, Sayegh MH, DeKruyff RH, Khoury SJ, Kuchroo VK. Xiao S, et al. Among authors: kuchroo vk. J Exp Med. 2007 Jul 9;204(7):1691-702. doi: 10.1084/jem.20062498. Epub 2007 Jul 2. J Exp Med. 2007. PMID: 17606630 Free PMC article.
T-bet, a Th1 transcription factor regulates the expression of Tim-3.
Anderson AC, Lord GM, Dardalhon V, Lee DH, Sabatos-Peyton CA, Glimcher LH, Kuchroo VK. Anderson AC, et al. Among authors: kuchroo vk. Eur J Immunol. 2010 Mar;40(3):859-66. doi: 10.1002/eji.200939842. Eur J Immunol. 2010. PMID: 20049876 Free PMC article.
447 results