Shortened engineered human antibody CH2 domains: increased stability and binding to the human neonatal Fc receptor.
Gong R, Wang Y, Feng Y, Zhao Q, Dimitrov DS.
Gong R, et al.
J Biol Chem. 2011 Aug 5;286(31):27288-93. doi: 10.1074/jbc.M111.254219. Epub 2011 Jun 13.
J Biol Chem. 2011.
PMID: 21669873
Free PMC article.
We have shown previously that an isolated human CH2 domain is relatively unstable to thermally induced unfolding, but its stability can be improved by engineering an additional disulfide bond (Gong, R., Vu, B. K., Feng, Y., Prieto, D. A., Dyba, M. A., Walsh, J. D., …
We have shown previously that an isolated human CH2 domain is relatively unstable to thermally induced unfolding, but its stability can be i …