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Engineered human antibody constant domains with increased stability.
Gong R, Vu BK, Feng Y, Prieto DA, Dyba MA, Walsh JD, Prabakaran P, Veenstra TD, Tarasov SG, Ishima R, Dimitrov DS. Gong R, et al. J Biol Chem. 2009 May 22;284(21):14203-10. doi: 10.1074/jbc.M900769200. Epub 2009 Mar 23. J Biol Chem. 2009. PMID: 19307178 Free PMC article.
Shortened engineered human antibody CH2 domains: increased stability and binding to the human neonatal Fc receptor.
Gong R, Wang Y, Feng Y, Zhao Q, Dimitrov DS. Gong R, et al. J Biol Chem. 2011 Aug 5;286(31):27288-93. doi: 10.1074/jbc.M111.254219. Epub 2011 Jun 13. J Biol Chem. 2011. PMID: 21669873 Free PMC article.
We have shown previously that an isolated human CH2 domain is relatively unstable to thermally induced unfolding, but its stability can be improved by engineering an additional disulfide bond (Gong, R., Vu, B. K., Feng, Y., Prieto, D. A., Dyba, M. A., Walsh, J. D., …
We have shown previously that an isolated human CH2 domain is relatively unstable to thermally induced unfolding, but its stability can be i …
Candidate antibody-based therapeutics against HIV-1.
Gong R, Chen W, Dimitrov DS. Gong R, et al. BioDrugs. 2012 Jun 1;26(3):143-62. doi: 10.2165/11631400-000000000-00000. BioDrugs. 2012. PMID: 22462520 Free PMC article. Review.
Soluble monomeric IgG1 Fc.
Ying T, Chen W, Gong R, Feng Y, Dimitrov DS. Ying T, et al. Among authors: gong r. J Biol Chem. 2012 Jun 1;287(23):19399-408. doi: 10.1074/jbc.M112.368647. Epub 2012 Apr 19. J Biol Chem. 2012. PMID: 22518843 Free PMC article.
1,058 results