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The cell cycle regulator 14-3-3σ opposes and reverses cancer metabolic reprogramming.
Phan L, Chou PC, Velazquez-Torres G, Samudio I, Parreno K, Huang Y, Tseng C, Vu T, Gully C, Su CH, Wang E, Chen J, Choi HH, Fuentes-Mattei E, Shin JH, Shiang C, Grabiner B, Blonska M, Skerl S, Shao Y, Cody D, Delacerda J, Kingsley C, Webb D, Carlock C, Zhou Z, Hsieh YC, Lee J, Elliott A, Ramirez M, Bankson J, Hazle J, Wang Y, Li L, Weng S, Rizk N, Wen YY, Lin X, Wang H, Wang H, Zhang A, Xia X, Wu Y, Habra M, Yang W, Pusztai L, Yeung SC, Lee MH. Phan L, et al. Among authors: grabiner b. Nat Commun. 2015 Jul 16;6:7530. doi: 10.1038/ncomms8530. Nat Commun. 2015. PMID: 26179207 Free PMC article.
The E3 ligase TRAF6 regulates Akt ubiquitination and activation.
Yang WL, Wang J, Chan CH, Lee SW, Campos AD, Lamothe B, Hur L, Grabiner BC, Lin X, Darnay BG, Lin HK. Yang WL, et al. Among authors: grabiner bc. Science. 2009 Aug 28;325(5944):1134-8. doi: 10.1126/science.1175065. Science. 2009. PMID: 19713527 Free PMC article.
MEKK3 is required for lysophosphatidic acid-induced NF-kappaB activation.
Sun W, Li H, Yu Y, Fan Y, Grabiner BC, Mao R, Ge N, Zhang H, Fu S, Lin X, Yang J. Sun W, et al. Among authors: grabiner bc. Cell Signal. 2009 Oct;21(10):1488-94. doi: 10.1016/j.cellsig.2009.05.007. Epub 2009 May 22. Cell Signal. 2009. PMID: 19465115 Free PMC article.
Constitutively active type I insulin-like growth factor receptor causes transformation and xenograft growth of immortalized mammary epithelial cells and is accompanied by an epithelial-to-mesenchymal transition mediated by NF-kappaB and snail.
Kim HJ, Litzenburger BC, Cui X, Delgado DA, Grabiner BC, Lin X, Lewis MT, Gottardis MM, Wong TW, Attar RM, Carboni JM, Lee AV. Kim HJ, et al. Mol Cell Biol. 2007 Apr;27(8):3165-75. doi: 10.1128/MCB.01315-06. Epub 2007 Feb 12. Mol Cell Biol. 2007. PMID: 17296734 Free PMC article.
Response and acquired resistance to everolimus in anaplastic thyroid cancer.
Wagle N, Grabiner BC, Van Allen EM, Amin-Mansour A, Taylor-Weiner A, Rosenberg M, Gray N, Barletta JA, Guo Y, Swanson SJ, Ruan DT, Hanna GJ, Haddad RI, Getz G, Kwiatkowski DJ, Carter SL, Sabatini DM, Jänne PA, Garraway LA, Lorch JH. Wagle N, et al. Among authors: grabiner bc. N Engl J Med. 2014 Oct 9;371(15):1426-33. doi: 10.1056/NEJMoa1403352. N Engl J Med. 2014. PMID: 25295501 Free PMC article.
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