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The cell cycle regulator 14-3-3σ opposes and reverses cancer metabolic reprogramming.
Phan L, Chou PC, Velazquez-Torres G, Samudio I, Parreno K, Huang Y, Tseng C, Vu T, Gully C, Su CH, Wang E, Chen J, Choi HH, Fuentes-Mattei E, Shin JH, Shiang C, Grabiner B, Blonska M, Skerl S, Shao Y, Cody D, Delacerda J, Kingsley C, Webb D, Carlock C, Zhou Z, Hsieh YC, Lee J, Elliott A, Ramirez M, Bankson J, Hazle J, Wang Y, Li L, Weng S, Rizk N, Wen YY, Lin X, Wang H, Wang H, Zhang A, Xia X, Wu Y, Habra M, Yang W, Pusztai L, Yeung SC, Lee MH. Phan L, et al. Among authors: su ch. Nat Commun. 2015 Jul 16;6:7530. doi: 10.1038/ncomms8530. Nat Commun. 2015. PMID: 26179207 Free PMC article.
CSN6 drives carcinogenesis by positively regulating Myc stability.
Chen J, Shin JH, Zhao R, Phan L, Wang H, Xue Y, Post SM, Ho Choi H, Chen JS, Wang E, Zhou Z, Tseng C, Gully C, Velazquez-Torres G, Fuentes-Mattei E, Yeung G, Qiao Y, Chou PC, Su CH, Hsieh YC, Hsu SL, Ohshiro K, Shaikenov T, Wang H, Yeung SC, Lee MH. Chen J, et al. Among authors: su ch. Nat Commun. 2014 Nov 14;5:5384. doi: 10.1038/ncomms6384. Nat Commun. 2014. PMID: 25395170 Free PMC article.
Roles for CSN5 in control of p53/MDM2 activities.
Zhang XC, Chen J, Su CH, Yang HY, Lee MH. Zhang XC, et al. Among authors: su ch. J Cell Biochem. 2008 Mar 1;103(4):1219-30. doi: 10.1002/jcb.21504. J Cell Biochem. 2008. PMID: 17879958
Aurora B kinase phosphorylates and instigates degradation of p53.
Gully CP, Velazquez-Torres G, Shin JH, Fuentes-Mattei E, Wang E, Carlock C, Chen J, Rothenberg D, Adams HP, Choi HH, Guma S, Phan L, Chou PC, Su CH, Zhang F, Chen JS, Yang TY, Yeung SC, Lee MH. Gully CP, et al. Among authors: su ch. Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):E1513-22. doi: 10.1073/pnas.1110287109. Epub 2012 May 18. Proc Natl Acad Sci U S A. 2012. PMID: 22611192 Free PMC article.
Exenatide improves glucocorticoid-induced glucose intolerance in mice.
Zhao R, Fuentes-Mattei E, Velazquez-Torres G, Su CH, Chen J, Lee MH, Yeung SC. Zhao R, et al. Among authors: su ch. Diabetes Metab Syndr Obes. 2011 Jan 26;4:61-5. doi: 10.2147/DMSO.S15510. Diabetes Metab Syndr Obes. 2011. PMID: 21448323 Free PMC article.
Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers.
Zhao R, Yeung SC, Chen J, Iwakuma T, Su CH, Chen B, Qu C, Zhang F, Chen YT, Lin YL, Lee DF, Jin F, Zhu R, Shaikenov T, Sarbassov D, Sahin A, Wang H, Wang H, Lai CC, Tsai FJ, Lozano G, Lee MH. Zhao R, et al. Among authors: su ch. J Clin Invest. 2011 Mar;121(3):851-65. doi: 10.1172/JCI44111. Epub 2011 Feb 7. J Clin Invest. 2011. PMID: 21317535 Free PMC article.
816 results