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Proteome-scale discovery of protein degradation and stabilization effectors.
Poirson J, Cho H, Dhillon A, Haider S, Imrit AZ, Lam MHY, Alerasool N, Lacoste J, Mizan L, Wong C, Gingras AC, Schramek D, Taipale M. Poirson J, et al. Among authors: alerasool n. Nature. 2024 Apr;628(8009):878-886. doi: 10.1038/s41586-024-07224-3. Epub 2024 Mar 20. Nature. 2024. PMID: 38509365
A universal deep-learning model for zinc finger design enables transcription factor reprogramming.
Ichikawa DM, Abdin O, Alerasool N, Kogenaru M, Mueller AL, Wen H, Giganti DO, Goldberg GW, Adams S, Spencer JM, Razavi R, Nim S, Zheng H, Gionco C, Clark FT, Strokach A, Hughes TR, Lionnet T, Taipale M, Kim PM, Noyes MB. Ichikawa DM, et al. Among authors: alerasool n. Nat Biotechnol. 2023 Aug;41(8):1117-1129. doi: 10.1038/s41587-022-01624-4. Epub 2023 Jan 26. Nat Biotechnol. 2023. PMID: 36702896 Free PMC article.
Recurrent chromosomal translocations in sarcomas create a megacomplex that mislocalizes NuA4/TIP60 to Polycomb target loci.
Sudarshan D, Avvakumov N, Lalonde ME, Alerasool N, Joly-Beauparlant C, Jacquet K, Mameri A, Lambert JP, Rousseau J, Lachance C, Paquet E, Herrmann L, Thonta Setty S, Loehr J, Bernardini MQ, Rouzbahman M, Gingras AC, Coulombe B, Droit A, Taipale M, Doyon Y, Côté J. Sudarshan D, et al. Among authors: alerasool n. Genes Dev. 2022 Jun 1;36(11-12):664-683. doi: 10.1101/gad.348982.121. Epub 2022 Jun 16. Genes Dev. 2022. PMID: 35710139 Free PMC article.
MRG Proteins Are Shared by Multiple Protein Complexes With Distinct Functions.
Devoucoux M, Roques C, Lachance C, Lashgari A, Joly-Beauparlant C, Jacquet K, Alerasool N, Prudente A, Taipale M, Droit A, Lambert JP, Hussein SMI, Côté J. Devoucoux M, et al. Among authors: alerasool n. Mol Cell Proteomics. 2022 Jul;21(7):100253. doi: 10.1016/j.mcpro.2022.100253. Epub 2022 May 28. Mol Cell Proteomics. 2022. PMID: 35636729 Free PMC article.
11 results