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Sirtuin1 Suppresses Osteoclastogenesis by Deacetylating FoxOs.
Kim HN, Han L, Iyer S, de Cabo R, Zhao H, O'Brien CA, Manolagas SC, Almeida M. Kim HN, et al. Among authors: de cabo r. Mol Endocrinol. 2015 Oct;29(10):1498-509. doi: 10.1210/me.2015-1133. Epub 2015 Aug 19. Mol Endocrinol. 2015. PMID: 26287518 Free PMC article.
FOXOs attenuate bone formation by suppressing Wnt signaling.
Iyer S, Ambrogini E, Bartell SM, Han L, Roberson PK, de Cabo R, Jilka RL, Weinstein RS, O'Brien CA, Manolagas SC, Almeida M. Iyer S, et al. Among authors: de cabo r. J Clin Invest. 2013 Aug;123(8):3409-19. doi: 10.1172/JCI68049. Epub 2013 Jul 15. J Clin Invest. 2013. PMID: 23867625 Free PMC article.
SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass.
Mercken EM, Mitchell SJ, Martin-Montalvo A, Minor RK, Almeida M, Gomes AP, Scheibye-Knudsen M, Palacios HH, Licata JJ, Zhang Y, Becker KG, Khraiwesh H, González-Reyes JA, Villalba JM, Baur JA, Elliott P, Westphal C, Vlasuk GP, Ellis JL, Sinclair DA, Bernier M, de Cabo R. Mercken EM, et al. Among authors: de cabo r. Aging Cell. 2014 Oct;13(5):787-96. doi: 10.1111/acel.12220. Epub 2014 Jun 16. Aging Cell. 2014. PMID: 24931715 Free PMC article.
Estrogens decrease osteoclast number by attenuating mitochondria oxidative phosphorylation and ATP production in early osteoclast precursors.
Kim HN, Ponte F, Nookaew I, Ucer Ozgurel S, Marques-Carvalho A, Iyer S, Warren A, Aykin-Burns N, Krager K, Sardao VA, Han L, de Cabo R, Zhao H, Jilka RL, Manolagas SC, Almeida M. Kim HN, et al. Among authors: de cabo r. Sci Rep. 2020 Jul 20;10(1):11933. doi: 10.1038/s41598-020-68890-7. Sci Rep. 2020. PMID: 32686739 Free PMC article.
Dietary activators of Sirt1.
Allard JS, Perez E, Zou S, de Cabo R. Allard JS, et al. Among authors: de cabo r. Mol Cell Endocrinol. 2009 Feb 5;299(1):58-63. doi: 10.1016/j.mce.2008.10.018. Epub 2008 Nov 1. Mol Cell Endocrinol. 2009. PMID: 19010386 Free PMC article. Review.
Negative regulation of STAT3 protein-mediated cellular respiration by SIRT1 protein.
Bernier M, Paul RK, Martin-Montalvo A, Scheibye-Knudsen M, Song S, He HJ, Armour SM, Hubbard BP, Bohr VA, Wang L, Zong Y, Sinclair DA, de Cabo R. Bernier M, et al. Among authors: de cabo r. J Biol Chem. 2011 Jun 3;286(22):19270-9. doi: 10.1074/jbc.M110.200311. Epub 2011 Apr 5. J Biol Chem. 2011. PMID: 21467030 Free PMC article.
Metformin improves healthspan and lifespan in mice.
Martin-Montalvo A, Mercken EM, Mitchell SJ, Palacios HH, Mote PL, Scheibye-Knudsen M, Gomes AP, Ward TM, Minor RK, Blouin MJ, Schwab M, Pollak M, Zhang Y, Yu Y, Becker KG, Bohr VA, Ingram DK, Sinclair DA, Wolf NS, Spindler SR, Bernier M, de Cabo R. Martin-Montalvo A, et al. Among authors: de cabo r. Nat Commun. 2013;4:2192. doi: 10.1038/ncomms3192. Nat Commun. 2013. PMID: 23900241 Free PMC article.
367 results