Hartmann RW - Search Results

1

Discovery of Triazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys.

Hoyt SB, Petrilli W, London C, Liang GB, Tata J, Hu Q, Yin L, van Koppen CJ, Hartmann RW, Struthers M, Wisniewski T, Ren N, Bopp C, Sok A, Cai TQ, Stribling S, Pai LY, Ma X, Metzger J, Verras A, McMasters D, Chen Q, Tung E, Tang W, Salituro G, Buist N, Clemas J, Zhou G, Gibson J, Maxwell CA, Lassman M, McLaughlin T, Castro-Perez J, Szeto D, Forrest G, Hajdu R, Rosenbach M, Xiong Y. Hoyt SB, et al. Among authors: hartmann rw. ACS Med Chem Lett. 2015 Jul 17;6(8):861-5. doi: 10.1021/acsmedchemlett.5b00048. eCollection 2015 Aug 13. ACS Med Chem Lett. 2015. PMID: 26288685 Free PMC article.

2

Synthesis and evaluation of 2'-substituted 4-(4'-carboxy- or 4'-carboxymethylbenzylidene)-N-acylpiperidines: highly potent and in vivo active steroid 5alpha-reductase type 2 inhibitors.

Picard F, Barassin S, Mokhtarian A, Hartmann RW. Picard F, et al. Among authors: hartmann rw. J Med Chem. 2002 Aug 1;45(16):3406-17. doi: 10.1021/jm0208471. J Med Chem. 2002. PMID: 12139451

3

Discovery of selective CYP11B2 (aldosterone synthase) inhibitors for the therapy of congestive heart failure and myocardial fibrosis.

Hartmann RW, Müller U, Ehmer PB. Hartmann RW, et al. Eur J Med Chem. 2003 Apr;38(4):363-6. doi: 10.1016/s0223-5234(03)00049-7. Eur J Med Chem. 2003. PMID: 12750023

4

Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitors of aldosterone synthase.

Ulmschneider S, Müller-Vieira U, Klein CD, Antes I, Lengauer T, Hartmann RW. Ulmschneider S, et al. Among authors: hartmann rw. J Med Chem. 2005 Mar 10;48(5):1563-75. doi: 10.1021/jm0492397. J Med Chem. 2005. PMID: 15743198

5

Synthesis and evaluation of imidazolylmethylenetetrahydronaphthalenes and imidazolylmethyleneindanes: potent inhibitors of aldosterone synthase.

Ulmschneider S, Müller-Vieira U, Mitrenga M, Hartmann RW, Oberwinkler-Marchais S, Klein CD, Bureik M, Bernhardt R, Antes I, Lengauer T. Ulmschneider S, et al. Among authors: hartmann rw. J Med Chem. 2005 Mar 24;48(6):1796-805. doi: 10.1021/jm049600p. J Med Chem. 2005. PMID: 15771425

6

Heteroaryl-substituted naphthalenes and structurally modified derivatives: selective inhibitors of CYP11B2 for the treatment of congestive heart failure and myocardial fibrosis.

Voets M, Antes I, Scherer C, Müller-Vieira U, Biemel K, Barassin C, Marchais-Oberwinkler S, Hartmann RW. Voets M, et al. Among authors: hartmann rw. J Med Chem. 2005 Oct 20;48(21):6632-42. doi: 10.1021/jm0503704. J Med Chem. 2005. PMID: 16220979

7

Development and evaluation of a pharmacophore model for inhibitors of aldosterone synthase (CYP11B2).

Ulmschneider S, Negri M, Voets M, Hartmann RW. Ulmschneider S, et al. Among authors: hartmann rw. Bioorg Med Chem Lett. 2006 Jan 1;16(1):25-30. doi: 10.1016/j.bmcl.2005.09.059. Epub 2005 Oct 21. Bioorg Med Chem Lett. 2006. PMID: 16246562

8

Novel 5alpha-reductase inhibitors: synthesis, structure-activity studies, and pharmacokinetic profile of phenoxybenzoylphenyl acetic acids.

Salem OI, Frotscher M, Scherer C, Neugebauer A, Biemel K, Streiber M, Maas R, Hartmann RW. Salem OI, et al. Among authors: hartmann rw. J Med Chem. 2006 Jan 26;49(2):748-59. doi: 10.1021/jm050728w. J Med Chem. 2006. PMID: 16420060

9

Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B2) for the treatment of congestive heart failure and myocardial fibrosis.

Voets M, Antes I, Scherer C, Müller-Vieira U, Biemel K, Marchais-Oberwinkler S, Hartmann RW. Voets M, et al. Among authors: hartmann rw. J Med Chem. 2006 Apr 6;49(7):2222-31. doi: 10.1021/jm060055x. J Med Chem. 2006. PMID: 16570918

10

Synthesis, biological evaluation and molecular modelling studies of methyleneimidazole substituted biaryls as inhibitors of human 17alpha-hydroxylase-17,20-lyase (CYP17). Part I: Heterocyclic modifications of the core structure.

Jagusch C, Negri M, Hille UE, Hu Q, Bartels M, Jahn-Hoffmann K, Pinto-Bazurco Mendieta MA, Rodenwaldt B, Müller-Vieira U, Schmidt D, Lauterbach T, Recanatini M, Cavalli A, Hartmann RW. Jagusch C, et al. Among authors: hartmann rw. Bioorg Med Chem. 2008 Feb 15;16(4):1992-2010. doi: 10.1016/j.bmc.2007.10.094. Epub 2007 Nov 4. Bioorg Med Chem. 2008. PMID: 18061460

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

345 results

Search Page