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Harmonising and linking biomedical and clinical data across disparate data archives to enable integrative cross-biobank research.
Spjuth O, Krestyaninova M, Hastings J, Shen HY, Heikkinen J, Waldenberger M, Langhammer A, Ladenvall C, Esko T, Persson MÅ, Heggland J, Dietrich J, Ose S, Gieger C, Ried JS, Peters A, Fortier I, de Geus EJ, Klovins J, Zaharenko L, Willemsen G, Hottenga JJ, Litton JE, Karvanen J, Boomsma DI, Groop L, Rung J, Palmgren J, Pedersen NL, McCarthy MI, van Duijn CM, Hveem K, Metspalu A, Ripatti S, Prokopenko I, Harris JR. Spjuth O, et al. Eur J Hum Genet. 2016 Apr;24(4):521-8. doi: 10.1038/ejhg.2015.165. Epub 2015 Aug 26. Eur J Hum Genet. 2016. PMID: 26306643 Free PMC article.
E-Science technologies in a workflow for personalized medicine using cancer screening as a case study.
Spjuth O, Karlsson A, Clements M, Humphreys K, Ivansson E, Dowling J, Eklund M, Jauhiainen A, Czene K, Grönberg H, Sparén P, Wiklund F, Cheddad A, Pálsdóttir Þ, Rantalainen M, Abrahamsson L, Laure E, Litton JE, Palmgren J. Spjuth O, et al. J Am Med Inform Assoc. 2017 Sep 1;24(5):950-957. doi: 10.1093/jamia/ocx038. J Am Med Inform Assoc. 2017. PMID: 28444384 Free PMC article.
The LCB Data Warehouse.
Ameur A, Yankovski V, Enroth S, Spjuth O, Komorowski J. Ameur A, et al. Among authors: spjuth o. Bioinformatics. 2006 Apr 15;22(8):1024-6. doi: 10.1093/bioinformatics/btl036. Epub 2006 Feb 2. Bioinformatics. 2006. PMID: 16455749
The ChEMBL database as linked open data.
Willighagen EL, Waagmeester A, Spjuth O, Ansell P, Williams AJ, Tkachenko V, Hastings J, Chen B, Wild DJ. Willighagen EL, et al. Among authors: spjuth o. J Cheminform. 2013 May 8;5(1):23. doi: 10.1186/1758-2946-5-23. J Cheminform. 2013. PMID: 23657106 Free PMC article.
Toxicology ontology perspectives.
Hardy B, Apic G, Carthew P, Clark D, Cook D, Dix I, Escher S, Hastings J, Heard DJ, Jeliazkova N, Judson P, Matis-Mitchell S, Mitic D, Myatt G, Shah I, Spjuth O, Tcheremenskaia O, Toldo L, Watson D, White A, Yang C. Hardy B, et al. Among authors: spjuth o. ALTEX. 2012;29(2):139-56. doi: 10.14573/altex.2012.2.139. ALTEX. 2012. PMID: 22562487 Free article. Review.
A toxicology ontology roadmap.
Hardy B, Apic G, Carthew P, Clark D, Cook D, Dix I, Escher S, Hastings J, Heard DJ, Jeliazkova N, Judson P, Matis-Mitchell S, Mitic D, Myatt G, Shah I, Spjuth O, Tcheremenskaia O, Toldo L, Watson D, White A, Yang C. Hardy B, et al. Among authors: spjuth o. ALTEX. 2012;29(2):129-37. doi: 10.14573/altex.2012.2.129. ALTEX. 2012. PMID: 22562486 Free article.
Cancer biology, toxicology and alternative methods development go hand-in-hand.
Kohonen P, Ceder R, Smit I, Hongisto V, Myatt G, Hardy B, Spjuth O, Grafström R. Kohonen P, et al. Among authors: spjuth o. Basic Clin Pharmacol Toxicol. 2014 Jul;115(1):50-8. doi: 10.1111/bcpt.12257. Epub 2014 May 23. Basic Clin Pharmacol Toxicol. 2014. PMID: 24779563 Free article. Review.
Ligand-based target prediction with signature fingerprints.
Alvarsson J, Eklund M, Engkvist O, Spjuth O, Carlsson L, Wikberg JE, Noeske T. Alvarsson J, et al. Among authors: spjuth o. J Chem Inf Model. 2014 Oct 27;54(10):2647-53. doi: 10.1021/ci500361u. Epub 2014 Oct 3. J Chem Inf Model. 2014. PMID: 25230336
113 results