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Harmonising and linking biomedical and clinical data across disparate data archives to enable integrative cross-biobank research.
Spjuth O, Krestyaninova M, Hastings J, Shen HY, Heikkinen J, Waldenberger M, Langhammer A, Ladenvall C, Esko T, Persson MÅ, Heggland J, Dietrich J, Ose S, Gieger C, Ried JS, Peters A, Fortier I, de Geus EJ, Klovins J, Zaharenko L, Willemsen G, Hottenga JJ, Litton JE, Karvanen J, Boomsma DI, Groop L, Rung J, Palmgren J, Pedersen NL, McCarthy MI, van Duijn CM, Hveem K, Metspalu A, Ripatti S, Prokopenko I, Harris JR. Spjuth O, et al. Among authors: zaharenko l. Eur J Hum Genet. 2016 Apr;24(4):521-8. doi: 10.1038/ejhg.2015.165. Epub 2015 Aug 26. Eur J Hum Genet. 2016. PMID: 26306643 Free PMC article.
Metformin Transport Rates Between Plasma and Red Blood Cells in Humans.
Kurlovics J, Zake DM, Zaharenko L, Berzins K, Klovins J, Stalidzans E. Kurlovics J, et al. Among authors: zaharenko l. Clin Pharmacokinet. 2022 Jan;61(1):133-142. doi: 10.1007/s40262-021-01058-2. Epub 2021 Jul 26. Clin Pharmacokinet. 2022. PMID: 34309806 Free PMC article.
Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin.
Zhou K, Yee SW, Seiser EL, van Leeuwen N, Tavendale R, Bennett AJ, Groves CJ, Coleman RL, van der Heijden AA, Beulens JW, de Keyser CE, Zaharenko L, Rotroff DM, Out M, Jablonski KA, Chen L, Javorský M, Židzik J, Levin AM, Williams LK, Dujic T, Semiz S, Kubo M, Chien HC, Maeda S, Witte JS, Wu L, Tkáč I, Kooy A, van Schaik RHN, Stehouwer CDA, Logie L; MetGen Investigators; DPP Investigators; ACCORD Investigators; Sutherland C, Klovins J, Pirags V, Hofman A, Stricker BH, Motsinger-Reif AA, Wagner MJ, Innocenti F, 't Hart LM, Holman RR, McCarthy MI, Hedderson MM, Palmer CNA, Florez JC, Giacomini KM, Pearson ER. Zhou K, et al. Among authors: zaharenko l. Nat Genet. 2016 Sep;48(9):1055-1059. doi: 10.1038/ng.3632. Epub 2016 Aug 8. Nat Genet. 2016. PMID: 27500523 Free PMC article.
Extending the Minimum Information About BIobank Data Sharing Terminology to Describe Samples, Sample Donors, and Events.
Eklund N, Andrianarisoa NH, van Enckevort E, Anton G, Debucquoy A, Müller H, Zaharenko L, Engels C, Ebert L, Neumann M, Geeraert J, T'Joen V, Demski H, Caboux É, Proynova R, Parodi B, Mate S, van Iperen E, Merino-Martinez R, Quinlan PR, Holub P, Silander K. Eklund N, et al. Among authors: zaharenko l. Biopreserv Biobank. 2020 Jun;18(3):155-164. doi: 10.1089/bio.2019.0129. Epub 2020 Apr 17. Biopreserv Biobank. 2020. PMID: 32302498 Free PMC article.
Association of metformin administration with gut microbiome dysbiosis in healthy volunteers.
Elbere I, Kalnina I, Silamikelis I, Konrade I, Zaharenko L, Sekace K, Radovica-Spalvina I, Fridmanis D, Gudra D, Pirags V, Klovins J. Elbere I, et al. Among authors: zaharenko l. PLoS One. 2018 Sep 27;13(9):e0204317. doi: 10.1371/journal.pone.0204317. eCollection 2018. PLoS One. 2018. PMID: 30261008 Free PMC article. Clinical Trial.
Baseline gut microbiome composition predicts metformin therapy short-term efficacy in newly diagnosed type 2 diabetes patients.
Elbere I, Silamikelis I, Dindune II, Kalnina I, Ustinova M, Zaharenko L, Silamikele L, Rovite V, Gudra D, Konrade I, Sokolovska J, Pirags V, Klovins J. Elbere I, et al. Among authors: zaharenko l. PLoS One. 2020 Oct 30;15(10):e0241338. doi: 10.1371/journal.pone.0241338. eCollection 2020. PLoS One. 2020. PMID: 33125401 Free PMC article.
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