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Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism.
Prusiner SB, Woerman AL, Mordes DA, Watts JC, Rampersaud R, Berry DB, Patel S, Oehler A, Lowe JK, Kravitz SN, Geschwind DH, Glidden DV, Halliday GM, Middleton LT, Gentleman SM, Grinberg LT, Giles K. Prusiner SB, et al. Among authors: watts jc. Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):E5308-17. doi: 10.1073/pnas.1514475112. Epub 2015 Aug 31. Proc Natl Acad Sci U S A. 2015. PMID: 26324905 Free PMC article.
Conformational transformation and selection of synthetic prion strains.
Ghaemmaghami S, Watts JC, Nguyen HO, Hayashi S, DeArmond SJ, Prusiner SB. Ghaemmaghami S, et al. Among authors: watts jc. J Mol Biol. 2011 Oct 28;413(3):527-42. doi: 10.1016/j.jmb.2011.07.021. Epub 2011 Aug 4. J Mol Biol. 2011. PMID: 21839745 Free PMC article.
Spontaneous generation of anchorless prions in transgenic mice.
Stöhr J, Watts JC, Legname G, Oehler A, Lemus A, Nguyen HO, Sussman J, Wille H, DeArmond SJ, Prusiner SB, Giles K. Stöhr J, et al. Among authors: watts jc. Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21223-8. doi: 10.1073/pnas.1117827108. Epub 2011 Dec 12. Proc Natl Acad Sci U S A. 2011. PMID: 22160704 Free PMC article.
Protease-resistant prions selectively decrease Shadoo protein.
Watts JC, Stöhr J, Bhardwaj S, Wille H, Oehler A, Dearmond SJ, Giles K, Prusiner SB. Watts JC, et al. PLoS Pathog. 2011 Nov;7(11):e1002382. doi: 10.1371/journal.ppat.1002382. Epub 2011 Nov 17. PLoS Pathog. 2011. PMID: 22163178 Free PMC article.
Purified and synthetic Alzheimer's amyloid beta (Aβ) prions.
Stöhr J, Watts JC, Mensinger ZL, Oehler A, Grillo SK, DeArmond SJ, Prusiner SB, Giles K. Stöhr J, et al. Among authors: watts jc. Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):11025-30. doi: 10.1073/pnas.1206555109. Epub 2012 Jun 18. Proc Natl Acad Sci U S A. 2012. PMID: 22711819 Free PMC article.
Drug resistance confounding prion therapeutics.
Berry DB, Lu D, Geva M, Watts JC, Bhardwaj S, Oehler A, Renslo AR, DeArmond SJ, Prusiner SB, Giles K. Berry DB, et al. Among authors: watts jc. Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):E4160-9. doi: 10.1073/pnas.1317164110. Epub 2013 Oct 15. Proc Natl Acad Sci U S A. 2013. PMID: 24128760 Free PMC article.
Transmission of multiple system atrophy prions to transgenic mice.
Watts JC, Giles K, Oehler A, Middleton L, Dexter DT, Gentleman SM, DeArmond SJ, Prusiner SB. Watts JC, et al. Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19555-60. doi: 10.1073/pnas.1318268110. Epub 2013 Nov 11. Proc Natl Acad Sci U S A. 2013. PMID: 24218576 Free PMC article.
Evidence that bank vole PrP is a universal acceptor for prions.
Watts JC, Giles K, Patel S, Oehler A, DeArmond SJ, Prusiner SB. Watts JC, et al. PLoS Pathog. 2014 Apr 3;10(4):e1003990. doi: 10.1371/journal.ppat.1003990. eCollection 2014 Apr. PLoS Pathog. 2014. PMID: 24699458 Free PMC article.
178 results