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Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism.
Prusiner SB, Woerman AL, Mordes DA, Watts JC, Rampersaud R, Berry DB, Patel S, Oehler A, Lowe JK, Kravitz SN, Geschwind DH, Glidden DV, Halliday GM, Middleton LT, Gentleman SM, Grinberg LT, Giles K. Prusiner SB, et al. Among authors: woerman al. Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):E5308-17. doi: 10.1073/pnas.1514475112. Epub 2015 Aug 31. Proc Natl Acad Sci U S A. 2015. PMID: 26324905 Free PMC article.
Propagation of prions causing synucleinopathies in cultured cells.
Woerman AL, Stöhr J, Aoyagi A, Rampersaud R, Krejciova Z, Watts JC, Ohyama T, Patel S, Widjaja K, Oehler A, Sanders DW, Diamond MI, Seeley WW, Middleton LT, Gentleman SM, Mordes DA, Südhof TC, Giles K, Prusiner SB. Woerman AL, et al. Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):E4949-58. doi: 10.1073/pnas.1513426112. Epub 2015 Aug 18. Proc Natl Acad Sci U S A. 2015. PMID: 26286986 Free PMC article.
α-Synuclein: Multiple System Atrophy Prions.
Woerman AL, Watts JC, Aoyagi A, Giles K, Middleton LT, Prusiner SB. Woerman AL, et al. Cold Spring Harb Perspect Med. 2018 Jul 2;8(7):a024588. doi: 10.1101/cshperspect.a024588. Cold Spring Harb Perspect Med. 2018. PMID: 28213437 Free PMC article. Review.
Bioassays and Inactivation of Prions.
Giles K, Woerman AL, Berry DB, Prusiner SB. Giles K, et al. Among authors: woerman al. Cold Spring Harb Perspect Biol. 2017 Aug 1;9(8):a023499. doi: 10.1101/cshperspect.a023499. Cold Spring Harb Perspect Biol. 2017. PMID: 28246183 Free PMC article. Review.
MSA prions exhibit remarkable stability and resistance to inactivation.
Woerman AL, Kazmi SA, Patel S, Freyman Y, Oehler A, Aoyagi A, Mordes DA, Halliday GM, Middleton LT, Gentleman SM, Olson SH, Prusiner SB. Woerman AL, et al. Acta Neuropathol. 2018 Jan;135(1):49-63. doi: 10.1007/s00401-017-1762-2. Epub 2017 Aug 28. Acta Neuropathol. 2018. PMID: 28849371 Free PMC article.
Aβ and tau prion-like activities decline with longevity in the Alzheimer's disease human brain.
Aoyagi A, Condello C, Stöhr J, Yue W, Rivera BM, Lee JC, Woerman AL, Halliday G, van Duinen S, Ingelsson M, Lannfelt L, Graff C, Bird TD, Keene CD, Seeley WW, DeGrado WF, Prusiner SB. Aoyagi A, et al. Among authors: woerman al. Sci Transl Med. 2019 May 1;11(490):eaat8462. doi: 10.1126/scitranslmed.aat8462. Sci Transl Med. 2019. PMID: 31043574 Free PMC article.
32 results