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The spliceosome is a therapeutic vulnerability in MYC-driven cancer.
Nature. 2015 Sep 17;525(7569):384-8. doi: 10.1038/nature14985. Epub 2015 Sep 2.
Nature. 2015.
PMID: 26331541
Free PMC article.
A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis.
Kessler JD, Kahle KT, Sun T, Meerbrey KL, Schlabach MR, Schmitt EM, Skinner SO, Xu Q, Li MZ, Hartman ZC, Rao M, Yu P, Dominguez-Vidana R, Liang AC, Solimini NL, Bernardi RJ, Yu B, Hsu T, Golding I, Luo J, Osborne CK, Creighton CJ, Hilsenbeck SG, Schiff R, Shaw CA, Elledge SJ, Westbrook TF.
Kessler JD, et al. Among authors: dominguez vidana r.
Science. 2012 Jan 20;335(6066):348-53. doi: 10.1126/science.1212728. Epub 2011 Dec 8.
Science. 2012.
PMID: 22157079
Free PMC article.
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Combinatorial inhibition of PTPN12-regulated receptors leads to a broadly effective therapeutic strategy in triple-negative breast cancer.
Nair A, Chung HC, Sun T, Tyagi S, Dobrolecki LE, Dominguez-Vidana R, Kurley SJ, Orellana M, Renwick A, Henke DM, Katsonis P, Schmitt E, Chan DW, Li H, Mao S, Petrovic I, Creighton CJ, Gutierrez C, Dubrulle J, Stossi F, Tyner JW, Lichtarge O, Lin CY, Zhang B, Scott KL, Hilsenbeck SG, Sun J, Yu X, Osborne CK, Schiff R, Christensen JG, Shields DJ, Rimawi MF, Ellis MJ, Shaw CA, Lewis MT, Westbrook TF.
Nair A, et al. Among authors: dominguez vidana r.
Nat Med. 2018 May;24(4):505-511. doi: 10.1038/nm.4507. Epub 2018 Mar 26.
Nat Med. 2018.
PMID: 29578538
Free PMC article.
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Spliceosome-targeted therapies trigger an antiviral immune response in triple-negative breast cancer.
Bowling EA, Wang JH, Gong F, Wu W, Neill NJ, Kim IS, Tyagi S, Orellana M, Kurley SJ, Dominguez-Vidaña R, Chung HC, Hsu TY, Dubrulle J, Saltzman AB, Li H, Meena JK, Canlas GM, Chamakuri S, Singh S, Simon LM, Olson CM, Dobrolecki LE, Lewis MT, Zhang B, Golding I, Rosen JM, Young DW, Malovannaya A, Stossi F, Miles G, Ellis MJ, Yu L, Buonamici S, Lin CY, Karlin KL, Zhang XH, Westbrook TF.
Bowling EA, et al. Among authors: dominguez vidana r.
Cell. 2021 Jan 21;184(2):384-403.e21. doi: 10.1016/j.cell.2020.12.031. Epub 2021 Jan 14.
Cell. 2021.
PMID: 33450205
Free PMC article.
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The oncogenic STP axis promotes triple-negative breast cancer via degradation of the REST tumor suppressor.
Karlin KL, Mondal G, Hartman JK, Tyagi S, Kurley SJ, Bland CS, Hsu TY, Renwick A, Fang JE, Migliaccio I, Callaway C, Nair A, Dominguez-Vidana R, Nguyen DX, Osborne CK, Schiff R, Yu-Lee LY, Jung SY, Edwards DP, Hilsenbeck SG, Rosen JM, Zhang XH, Shaw CA, Couch FJ, Westbrook TF.
Karlin KL, et al. Among authors: dominguez vidana r.
Cell Rep. 2014 Nov 20;9(4):1318-32. doi: 10.1016/j.celrep.2014.10.011. Epub 2014 Nov 6.
Cell Rep. 2014.
PMID: 25453754
Free PMC article.
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Identical repeated backbone of the human genome.
Zepeda-Mendoza CJ, Lemus T, Yáñez O, García D, Valle-García D, Meza-Sosa KF, Gutiérrez-Arcelus M, Márquez-Ortiz Y, Domínguez-Vidaña R, Gonzaga-Jauregui C, Flores M, Palacios R.
Zepeda-Mendoza CJ, et al. Among authors: dominguez vidana r.
BMC Genomics. 2010 Jan 23;11:60. doi: 10.1186/1471-2164-11-60.
BMC Genomics. 2010.
PMID: 20096123
Free PMC article.
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Recurrent DNA inversion rearrangements in the human genome.
Flores M, Morales L, Gonzaga-Jauregui C, Domínguez-Vidaña R, Zepeda C, Yañez O, Gutiérrez M, Lemus T, Valle D, Avila MC, Blanco D, Medina-Ruiz S, Meza K, Ayala E, García D, Bustos P, González V, Girard L, Tusie-Luna T, Dávila G, Palacios R.
Flores M, et al. Among authors: dominguez vidana r.
Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6099-106. doi: 10.1073/pnas.0701631104. Epub 2007 Mar 26.
Proc Natl Acad Sci U S A. 2007.
PMID: 17389356
Free PMC article.
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