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The spliceosome is a therapeutic vulnerability in MYC-driven cancer.
Hsu TY, Simon LM, Neill NJ, Marcotte R, Sayad A, Bland CS, Echeverria GV, Sun T, Kurley SJ, Tyagi S, Karlin KL, Dominguez-Vidaña R, Hartman JD, Renwick A, Scorsone K, Bernardi RJ, Skinner SO, Jain A, Orellana M, Lagisetti C, Golding I, Jung SY, Neilson JR, Zhang XH, Cooper TA, Webb TR, Neel BG, Shaw CA, Westbrook TF. Hsu TY, et al. Among authors: lagisetti c. Nature. 2015 Sep 17;525(7569):384-8. doi: 10.1038/nature14985. Epub 2015 Sep 2. Nature. 2015. PMID: 26331541 Free PMC article.
Optimization of antitumor modulators of pre-mRNA splicing.
Lagisetti C, Palacios G, Goronga T, Freeman B, Caufield W, Webb TR. Lagisetti C, et al. J Med Chem. 2013 Dec 27;56(24):10033-44. doi: 10.1021/jm401370h. Epub 2013 Dec 11. J Med Chem. 2013. PMID: 24325474 Free PMC article.
Sudemycin E influences alternative splicing and changes chromatin modifications.
Convertini P, Shen M, Potter PM, Palacios G, Lagisetti C, de la Grange P, Horbinski C, Fondufe-Mittendorf YN, Webb TR, Stamm S. Convertini P, et al. Among authors: lagisetti c. Nucleic Acids Res. 2014 Apr;42(8):4947-61. doi: 10.1093/nar/gku151. Epub 2014 Mar 11. Nucleic Acids Res. 2014. PMID: 24623796 Free PMC article.
The splicing modulator sudemycin induces a specific antitumor response and cooperates with ibrutinib in chronic lymphocytic leukemia.
Xargay-Torrent S, López-Guerra M, Rosich L, Montraveta A, Roldán J, Rodríguez V, Villamor N, Aymerich M, Lagisetti C, Webb TR, López-Otín C, Campo E, Colomer D. Xargay-Torrent S, et al. Among authors: lagisetti c. Oncotarget. 2015 Sep 8;6(26):22734-49. doi: 10.18632/oncotarget.4212. Oncotarget. 2015. PMID: 26068951 Free PMC article.
20 results