Osmand AP - Search Results

1

Novel BAC Mouse Model of Huntington's Disease with 225 CAG Repeats Exhibits an Early Widespread and Stable Degenerative Phenotype.

Wegrzynowicz M, Bichell TJ, Soares BD, Loth MK, McGlothan JS, Mori S, Alikhan FS, Hua K, Coughlin JM, Holt HK, Jetter CS, Pomper MG, Osmand AP, Guilarte TR, Bowman AB. Wegrzynowicz M, et al. Among authors: osmand ap. J Huntingtons Dis. 2015;4(1):17-36. J Huntingtons Dis. 2015. PMID: 26333255 Free PMC article.

2

Embryonic Mutant Huntingtin Aggregate Formation in Mouse Models of Huntington's Disease.

Osmand AP, Bichell TJ, Bowman AB, Bates GP. Osmand AP, et al. J Huntingtons Dis. 2016 Dec 15;5(4):343-346. doi: 10.3233/JHD-160217. J Huntingtons Dis. 2016. PMID: 27886014 Free PMC article.

3

Reduced bioavailable manganese causes striatal urea cycle pathology in Huntington's disease mouse model.

Bichell TJV, Wegrzynowicz M, Tipps KG, Bradley EM, Uhouse MA, Bryan M, Horning K, Fisher N, Dudek K, Halbesma T, Umashanker P, Stubbs AD, Holt HK, Kwakye GF, Tidball AM, Colbran RJ, Aschner M, Neely MD, Di Pardo A, Maglione V, Osmand A, Bowman AB. Bichell TJV, et al. Biochim Biophys Acta Mol Basis Dis. 2017 Jun;1863(6):1596-1604. doi: 10.1016/j.bbadis.2017.02.013. Epub 2017 Feb 16. Biochim Biophys Acta Mol Basis Dis. 2017. PMID: 28213125 Free PMC article.

4

Striatal Mutant Huntingtin Protein Levels Decline with Age in Homozygous Huntington's Disease Knock-In Mouse Models.

Franich NR, Basso M, André EA, Ochaba J, Kumar A, Thein S, Fote G, Kachemov M, Lau AL, Yeung SY, Osmand A, Zeitlin SO, Ratan RR, Thompson LM, Steffan JS. Franich NR, et al. J Huntingtons Dis. 2018;7(2):137-150. doi: 10.3233/JHD-170274. J Huntingtons Dis. 2018. PMID: 29843246 Free PMC article.

5

Further molecular characterisation of the OVT73 transgenic sheep model of Huntington's disease identifies cortical aggregates.

Huntington's Disease Sheep Collaborative Research Group; Reid SJ, Patassini S, Handley RR, Rudiger SR, McLaughlan CJ, Osmand A, Jacobsen JC, Morton AJ, Weiss A, Waldvogel HJ, MacDonald ME, Gusella JF, Bawden CS, Faull RL, Snell RG. Huntington's Disease Sheep Collaborative Research Group, et al. J Huntingtons Dis. 2013;2(3):279-95. doi: 10.3233/JHD-130067. J Huntingtons Dis. 2013. PMID: 25062676

6

Early autophagic response in a novel knock-in model of Huntington disease.

Heng MY, Duong DK, Albin RL, Tallaksen-Greene SJ, Hunter JM, Lesort MJ, Osmand A, Paulson HL, Detloff PJ. Heng MY, et al. Hum Mol Genet. 2010 Oct 1;19(19):3702-20. doi: 10.1093/hmg/ddq285. Epub 2010 Jul 8. Hum Mol Genet. 2010. PMID: 20616151 Free PMC article.

7

αB-Crystallin overexpression in astrocytes modulates the phenotype of the BACHD mouse model of Huntington's disease.

Oliveira AO, Osmand A, Outeiro TF, Muchowski PJ, Finkbeiner S. Oliveira AO, et al. Hum Mol Genet. 2016 May 1;25(9):1677-89. doi: 10.1093/hmg/ddw028. Epub 2016 Feb 26. Hum Mol Genet. 2016. PMID: 26920069 Free PMC article.

8

Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease.

Lu XH, Mattis VB, Wang N, Al-Ramahi I, van den Berg N, Fratantoni SA, Waldvogel H, Greiner E, Osmand A, Elzein K, Xiao J, Dijkstra S, de Pril R, Vinters HV, Faull R, Signer E, Kwak S, Marugan JJ, Botas J, Fischer DF, Svendsen CN, Munoz-Sanjuan I, Yang XW. Lu XH, et al. Sci Transl Med. 2014 Dec 24;6(268):268ra178. doi: 10.1126/scitranslmed.3010523. Sci Transl Med. 2014. PMID: 25540325

9

Coexistence of Huntington's disease and amyotrophic lateral sclerosis: a clinicopathologic study.

Tada M, Coon EA, Osmand AP, Kirby PA, Martin W, Wieler M, Shiga A, Shirasaki H, Tada M, Makifuchi T, Yamada M, Kakita A, Nishizawa M, Takahashi H, Paulson HL. Tada M, et al. Among authors: osmand ap. Acta Neuropathol. 2012 Nov;124(5):749-60. doi: 10.1007/s00401-012-1005-5. Epub 2012 Jun 27. Acta Neuropathol. 2012. PMID: 22735976 Free PMC article.

10

A novel BACHD transgenic rat exhibits characteristic neuropathological features of Huntington disease.

Yu-Taeger L, Petrasch-Parwez E, Osmand AP, Redensek A, Metzger S, Clemens LE, Park L, Howland D, Calaminus C, Gu X, Pichler B, Yang XW, Riess O, Nguyen HP. Yu-Taeger L, et al. Among authors: osmand ap. J Neurosci. 2012 Oct 31;32(44):15426-38. doi: 10.1523/JNEUROSCI.1148-12.2012. J Neurosci. 2012. PMID: 23115180 Free PMC article.

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