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The E3 ligase RNF43 inhibits Wnt signaling downstream of mutated β-catenin by sequestering TCF4 to the nuclear membrane.
Loregger A, Grandl M, Mejías-Luque R, Allgäuer M, Degenhart K, Haselmann V, Oikonomou C, Hatzis P, Janssen KP, Nitsche U, Gradl D, van den Broek O, Destree O, Ulm K, Neumaier M, Kalali B, Jung A, Varela I, Schmid RM, Rad R, Busch DH, Gerhard M. Loregger A, et al. Among authors: janssen kp. Sci Signal. 2015 Sep 8;8(393):ra90. doi: 10.1126/scisignal.aac6757. Sci Signal. 2015. PMID: 26350900
Colorectal cancer surgery remains effective with rising patient age.
Nitsche U, Späth C, Müller TC, Maak M, Janssen KP, Wilhelm D, Kleeff J, Bader FG. Nitsche U, et al. Among authors: janssen kp. Int J Colorectal Dis. 2014 Aug;29(8):971-9. doi: 10.1007/s00384-014-1914-y. Epub 2014 Jun 13. Int J Colorectal Dis. 2014. PMID: 24924447 Free PMC article.
MicroRNA classifier and nomogram for metastasis prediction in colon cancer.
Goossens-Beumer IJ, Derr RS, Buermans HP, Goeman JJ, Böhringer S, Morreau H, Nitsche U, Janssen KP, van de Velde CJ, Kuppen PJ. Goossens-Beumer IJ, et al. Among authors: janssen kp. Cancer Epidemiol Biomarkers Prev. 2015 Jan;24(1):187-97. doi: 10.1158/1055-9965.EPI-14-0544-T. Epub 2014 Oct 14. Cancer Epidemiol Biomarkers Prev. 2015. PMID: 25315964
192 results