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The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials.
Kottaridis PD, Gale RE, Frew ME, Harrison G, Langabeer SE, Belton AA, Walker H, Wheatley K, Bowen DT, Burnett AK, Goldstone AH, Linch DC. Kottaridis PD, et al. Among authors: bowen dt. Blood. 2001 Sep 15;98(6):1752-9. doi: 10.1182/blood.v98.6.1752. Blood. 2001. PMID: 11535508 Free article. Clinical Trial.
Studies of FLT3 mutations in paired presentation and relapse samples from patients with acute myeloid leukemia: implications for the role of FLT3 mutations in leukemogenesis, minimal residual disease detection, and possible therapy with FLT3 inhibitors.
Kottaridis PD, Gale RE, Langabeer SE, Frew ME, Bowen DT, Linch DC. Kottaridis PD, et al. Among authors: bowen dt. Blood. 2002 Oct 1;100(7):2393-8. doi: 10.1182/blood-2002-02-0420. Blood. 2002. PMID: 12239147 Free article.
Evidence for reduced B-cell progenitors in early (low-risk) myelodysplastic syndrome.
Sternberg A, Killick S, Littlewood T, Hatton C, Peniket A, Seidl T, Soneji S, Leach J, Bowen D, Chapman C, Standen G, Massey E, Robinson L, Vadher B, Kaczmarski R, Janmohammed R, Clipsham K, Carr A, Vyas P. Sternberg A, et al. Blood. 2005 Nov 1;106(9):2982-91. doi: 10.1182/blood-2005-04-1543. Epub 2005 Aug 2. Blood. 2005. PMID: 16076868 Free article.
Microarray-based classifiers and prognosis models identify subgroups with distinct clinical outcomes and high risk of AML transformation of myelodysplastic syndrome.
Mills KI, Kohlmann A, Williams PM, Wieczorek L, Liu WM, Li R, Wei W, Bowen DT, Loeffler H, Hernandez JM, Hofmann WK, Haferlach T. Mills KI, et al. Among authors: bowen dt. Blood. 2009 Jul 30;114(5):1063-72. doi: 10.1182/blood-2008-10-187203. Epub 2009 May 14. Blood. 2009. PMID: 19443663 Free article.
Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms.
Malcovati L, Papaemmanuil E, Bowen DT, Boultwood J, Della Porta MG, Pascutto C, Travaglino E, Groves MJ, Godfrey AL, Ambaglio I, Gallì A, Da Vià MC, Conte S, Tauro S, Keenan N, Hyslop A, Hinton J, Mudie LJ, Wainscoat JS, Futreal PA, Stratton MR, Campbell PJ, Hellström-Lindberg E, Cazzola M; Chronic Myeloid Disorders Working Group of the International Cancer Genome Consortium and of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative. Malcovati L, et al. Among authors: bowen dt. Blood. 2011 Dec 8;118(24):6239-46. doi: 10.1182/blood-2011-09-377275. Epub 2011 Oct 12. Blood. 2011. PMID: 21998214 Free PMC article.
Revised international prognostic scoring system for myelodysplastic syndromes.
Greenberg PL, Tuechler H, Schanz J, Sanz G, Garcia-Manero G, Solé F, Bennett JM, Bowen D, Fenaux P, Dreyfus F, Kantarjian H, Kuendgen A, Levis A, Malcovati L, Cazzola M, Cermak J, Fonatsch C, Le Beau MM, Slovak ML, Krieger O, Luebbert M, Maciejewski J, Magalhaes SM, Miyazaki Y, Pfeilstöcker M, Sekeres M, Sperr WR, Stauder R, Tauro S, Valent P, Vallespi T, van de Loosdrecht AA, Germing U, Haase D. Greenberg PL, et al. Blood. 2012 Sep 20;120(12):2454-65. doi: 10.1182/blood-2012-03-420489. Epub 2012 Jun 27. Blood. 2012. PMID: 22740453 Free PMC article.
181 results