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Selective targeting of JAK/STAT signaling is potentiated by Bcl-xL blockade in IL-2-dependent adult T-cell leukemia.
Zhang M, Mathews Griner LA, Ju W, Duveau DY, Guha R, Petrus MN, Wen B, Maeda M, Shinn P, Ferrer M, Conlon KD, Bamford RN, O'Shea JJ, Thomas CJ, Waldmann TA. Zhang M, et al. Among authors: petrus mn. Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):12480-5. doi: 10.1073/pnas.1516208112. Epub 2015 Sep 22. Proc Natl Acad Sci U S A. 2015. PMID: 26396258 Free PMC article.
Cytokine receptor signaling is required for the survival of ALK- anaplastic large cell lymphoma, even in the presence of JAK1/STAT3 mutations.
Chen J, Zhang Y, Petrus MN, Xiao W, Nicolae A, Raffeld M, Pittaluga S, Bamford RN, Nakagawa M, Ouyang ST, Epstein AL, Kadin ME, Del Mistro A, Woessner R, Jaffe ES, Waldmann TA. Chen J, et al. Among authors: petrus mn. Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):3975-3980. doi: 10.1073/pnas.1700682114. Epub 2017 Mar 29. Proc Natl Acad Sci U S A. 2017. PMID: 28356514 Free PMC article.
IL-2 receptors preassemble and signal in the ER/Golgi causing resistance to antiproliferative anti-IL-2Rα therapies.
Volkó J, Kenesei Á, Zhang M, Várnai P, Mocsár G, Petrus MN, Jambrovics K, Balajthy Z, Müller G, Bodnár A, Tóth K, Waldmann TA, Vámosi G. Volkó J, et al. Among authors: petrus mn. Proc Natl Acad Sci U S A. 2019 Oct 15;116(42):21120-21130. doi: 10.1073/pnas.1901382116. Epub 2019 Sep 30. Proc Natl Acad Sci U S A. 2019. PMID: 31570576 Free PMC article.
Preclinical and phase I clinical trial of blockade of IL-15 using Mikbeta1 monoclonal antibody in T cell large granular lymphocyte leukemia.
Morris JC, Janik JE, White JD, Fleisher TA, Brown M, Tsudo M, Goldman CK, Bryant B, Petrus M, Top L, Lee CC, Gao W, Waldmann TA. Morris JC, et al. Proc Natl Acad Sci U S A. 2006 Jan 10;103(2):401-6. doi: 10.1073/pnas.0509575103. Epub 2005 Dec 30. Proc Natl Acad Sci U S A. 2006. PMID: 16387851 Free PMC article. Clinical Trial.
A new domain in the Toll/IL-1R domain-containing adaptor inducing interferon-β factor protein amino terminus is important for tumor necrosis factor-α receptor-associated factor 3 association, protein stabilization and interferon signaling.
Nguyen VP, Chen J, Petrus MN, Goldman CK, Kruhlak MJ, Bamford RN, Waldmann TA. Nguyen VP, et al. Among authors: petrus mn. J Innate Immun. 2014;6(3):377-93. doi: 10.1159/000356408. Epub 2014 Feb 26. J Innate Immun. 2014. PMID: 24577058 Free PMC article.
27 results