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Discovery of 2-Pyridinone Aminals: A Prodrug Strategy to Advance a Second Generation of HIV-1 Integrase Strand Transfer Inhibitors.
Raheem IT, Walji AM, Klein D, Sanders JM, Powell DA, Abeywickrema P, Barbe G, Bennet A, Childers K, Christensen M, Clas SD, Dubost D, Embrey M, Grobler J, Hafey MJ, Hartingh TJ, Hazuda DJ, Kuethe JT, McCabe Dunn J, Miller MD, Moore KP, Nolting A, Pajkovic N, Patel S, Peng Z, Rada V, Rearden P, Schreier JD, Sisko J, Steele TG, Truchon JF, Wai J, Xu M, Coleman PJ. Raheem IT, et al. Among authors: christensen m. J Med Chem. 2015 Oct 22;58(20):8154-65. doi: 10.1021/acs.jmedchem.5b01037. Epub 2015 Oct 8. J Med Chem. 2015. PMID: 26397965
Correction to Discovery of 2-Pyridinone Aminals: A Prodrug Strategy to Advance a Second Generation of HIV-1 Integrase Strand Transfer Inhibitors.
Raheem IT, Walji AM, Klein D, Sanders JM, Powell DA, Abeywickrema P, Barbe G, Bennet A, Childers K, Christensen M, Clas SD, Dubost D, Embrey M, Grobler J, Hafey MJ, Hartingh TJ, Hazuda DJ, Kuethe JT, McCabe Dunn J, Miller MD, Moore KP, Nolting A, Pajkovic N, Patel S, Peng Z, Rada V, Rearden P, Schreier JD, Sisko J, Steele TG, Truchon JF, Wai J, Xu M, Coleman PJ. Raheem IT, et al. Among authors: christensen m. J Med Chem. 2016 Jan 14;59(1):486. doi: 10.1021/acs.jmedchem.5b01957. Epub 2015 Dec 28. J Med Chem. 2016. PMID: 26709958 No abstract available.
Enantioselective Synthesis of α-Methyl-β-cyclopropyldihydrocinnamates.
Christensen M, Nolting A, Shevlin M, Weisel M, Maligres PE, Lee J, Orr RK, Plummer CW, Tudge MT, Campeau LC, Ruck RT. Christensen M, et al. J Org Chem. 2016 Feb 5;81(3):824-30. doi: 10.1021/acs.joc.5b02296. Epub 2016 Jan 25. J Org Chem. 2016. PMID: 26743694
Design and Synthesis of Novel, Selective GPR40 AgoPAMs.
Plummer CW, Clements MJ, Chen H, Rajagopalan M, Josien H, Hagmann WK, Miller M, Trujillo ME, Kirkland M, Kosinski D, Mane J, Pachanski M, Cheewatrakoolpong B, Nolting AF, Orr R, Christensen M, Campeau LC, Wright MJ, Bugianesi R, Souza S, Zhang X, Di Salvo J, Weinglass AB, Tschirret-Guth R, Nargund R, Howard AD, Colletti SL. Plummer CW, et al. Among authors: christensen m. ACS Med Chem Lett. 2017 Jan 23;8(2):221-226. doi: 10.1021/acsmedchemlett.6b00443. eCollection 2017 Feb 9. ACS Med Chem Lett. 2017. PMID: 28197316 Free PMC article.
Enantioselective synthesis of an HCV NS5a antagonist.
Mangion IK, Chen CY, Li H, Maligres P, Chen Y, Christensen M, Cohen R, Jeon I, Klapars A, Krska S, Nguyen H, Reamer RA, Sherry BD, Zavialov I. Mangion IK, et al. Among authors: christensen m. Org Lett. 2014 May 2;16(9):2310-3. doi: 10.1021/ol500971c. Epub 2014 Apr 11. Org Lett. 2014. PMID: 24724971
Data-science driven autonomous process optimization.
Christensen M, Yunker LPE, Adedeji F, Häse F, Roch LM, Gensch T, Dos Passos Gomes G, Zepel T, Sigman MS, Aspuru-Guzik A, Hein JE. Christensen M, et al. Commun Chem. 2021 Aug 2;4(1):112. doi: 10.1038/s42004-021-00550-x. Commun Chem. 2021. PMID: 36697524 Free PMC article.
Automation isn't automatic.
Christensen M, Yunker LPE, Shiri P, Zepel T, Prieto PL, Grunert S, Bork F, Hein JE. Christensen M, et al. Chem Sci. 2021 Oct 27;12(47):15473-15490. doi: 10.1039/d1sc04588a. eCollection 2021 Dec 8. Chem Sci. 2021. PMID: 35003576 Free PMC article. Review.
Dynamic sampling in autonomous process optimization.
Christensen M, Xu Y, Kwan EE, Di Maso MJ, Ji Y, Reibarkh M, Sun AC, Liaw A, Fier PS, Grosser S, Hein JE. Christensen M, et al. Chem Sci. 2024 Apr 11;15(19):7160-7169. doi: 10.1039/d3sc06884f. eCollection 2024 May 15. Chem Sci. 2024. PMID: 38756794 Free PMC article.
2,302 results