Barbieri CM - Search Results

1

Selective small-molecule inhibition of an RNA structural element.

Howe JA, Wang H, Fischmann TO, Balibar CJ, Xiao L, Galgoci AM, Malinverni JC, Mayhood T, Villafania A, Nahvi A, Murgolo N, Barbieri CM, Mann PA, Carr D, Xia E, Zuck P, Riley D, Painter RE, Walker SS, Sherborne B, de Jesus R, Pan W, Plotkin MA, Wu J, Rindgen D, Cummings J, Garlisi CG, Zhang R, Sheth PR, Gill CJ, Tang H, Roemer T. Howe JA, et al. Among authors: barbieri cm. Nature. 2015 Oct 29;526(7575):672-7. doi: 10.1038/nature15542. Epub 2015 Sep 30. Nature. 2015. PMID: 26416753

2

Dual-Targeting Small-Molecule Inhibitors of the Staphylococcus aureus FMN Riboswitch Disrupt Riboflavin Homeostasis in an Infectious Setting.

Wang H, Mann PA, Xiao L, Gill C, Galgoci AM, Howe JA, Villafania A, Barbieri CM, Malinverni JC, Sher X, Mayhood T, McCurry MD, Murgolo N, Flattery A, Mack M, Roemer T. Wang H, et al. Among authors: barbieri cm. Cell Chem Biol. 2017 May 18;24(5):576-588.e6. doi: 10.1016/j.chembiol.2017.03.014. Epub 2017 Apr 20. Cell Chem Biol. 2017. PMID: 28434876 Free article.

3

Validation and Development of an Escherichia coli Riboflavin Pathway Phenotypic Screen Hit as a Small-Molecule Ligand of the Flavin Mononucleotide Riboswitch.

Balibar CJ, Villafania A, Barbieri CM, Murgolo N, Roemer T, Wang H, Howe JA. Balibar CJ, et al. Among authors: barbieri cm. Methods Mol Biol. 2018;1787:19-40. doi: 10.1007/978-1-4939-7847-2_2. Methods Mol Biol. 2018. PMID: 29736707

4

Atomic resolution mechanistic studies of ribocil: A highly selective unnatural ligand mimic of the E. coli FMN riboswitch.

Howe JA, Xiao L, Fischmann TO, Wang H, Tang H, Villafania A, Zhang R, Barbieri CM, Roemer T. Howe JA, et al. Among authors: barbieri cm. RNA Biol. 2016 Oct 2;13(10):946-954. doi: 10.1080/15476286.2016.1216304. Epub 2016 Aug 2. RNA Biol. 2016. PMID: 27485612 Free PMC article.

5

Moderate to high throughput in vitro binding kinetics for drug discovery.

Zhang R, Barbieri CM, Garcia-Calvo M, Myers RW, McLaren D, Kavana M. Zhang R, et al. Among authors: barbieri cm. Front Biosci (Schol Ed). 2016 Jun 1;8(2):278-97. doi: 10.2741/s462. Front Biosci (Schol Ed). 2016. PMID: 27100706 Free article. Review.

6

Aminoglycoside complexation with a DNA.RNA hybrid duplex: the thermodynamics of recognition and inhibition of RNA processing enzymes.

Barbieri CM, Li TK, Guo S, Wang G, Shallop AJ, Pan W, Yang G, Gaffney BL, Jones RA, Pilch DS. Barbieri CM, et al. J Am Chem Soc. 2003 May 28;125(21):6469-77. doi: 10.1021/ja021371d. J Am Chem Soc. 2003. PMID: 12785787

7

Comprehensive analysis of OmpR phosphorylation, dimerization, and DNA binding supports a canonical model for activation.

Barbieri CM, Wu T, Stock AM. Barbieri CM, et al. J Mol Biol. 2013 May 27;425(10):1612-26. doi: 10.1016/j.jmb.2013.02.003. Epub 2013 Feb 8. J Mol Biol. 2013. PMID: 23399542 Free PMC article.

8

Thermodynamics of aminoglycoside-rRNA recognition.

Pilch DS, Kaul M, Barbieri CM, Kerrigan JE. Pilch DS, et al. Among authors: barbieri cm. Biopolymers. 2003 Sep;70(1):58-79. doi: 10.1002/bip.10411. Biopolymers. 2003. PMID: 12925993 Review.

9

Fluorescence-based approach for detecting and characterizing antibiotic-induced conformational changes in ribosomal RNA: comparing aminoglycoside binding to prokaryotic and eukaryotic ribosomal RNA sequences.

Kaul M, Barbieri CM, Pilch DS. Kaul M, et al. Among authors: barbieri cm. J Am Chem Soc. 2004 Mar 24;126(11):3447-53. doi: 10.1021/ja030568i. J Am Chem Soc. 2004. PMID: 15025471

10

Drug targeting of HIV-1 RNA.DNA hybrid structures: thermodynamics of recognition and impact on reverse transcriptase-mediated ribonuclease H activity and viral replication.

Li TK, Barbieri CM, Lin HC, Rabson AB, Yang G, Fan Y, Gaffney BL, Jones RA, Pilch DS. Li TK, et al. Among authors: barbieri cm. Biochemistry. 2004 Aug 3;43(30):9732-42. doi: 10.1021/bi0497345. Biochemistry. 2004. PMID: 15274628

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