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High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response.
Gao H, Korn JM, Ferretti S, Monahan JE, Wang Y, Singh M, Zhang C, Schnell C, Yang G, Zhang Y, Balbin OA, Barbe S, Cai H, Casey F, Chatterjee S, Chiang DY, Chuai S, Cogan SM, Collins SD, Dammassa E, Ebel N, Embry M, Green J, Kauffmann A, Kowal C, Leary RJ, Lehar J, Liang Y, Loo A, Lorenzana E, Robert McDonald E 3rd, McLaughlin ME, Merkin J, Meyer R, Naylor TL, Patawaran M, Reddy A, Röelli C, Ruddy DA, Salangsang F, Santacroce F, Singh AP, Tang Y, Tinetto W, Tobler S, Velazquez R, Venkatesan K, Von Arx F, Wang HQ, Wang Z, Wiesmann M, Wyss D, Xu F, Bitter H, Atadja P, Lees E, Hofmann F, Li E, Keen N, Cozens R, Jensen MR, Pryer NK, Williams JA, Sellers WR. Gao H, et al. Among authors: merkin j. Nat Med. 2015 Nov;21(11):1318-25. doi: 10.1038/nm.3954. Epub 2015 Oct 19. Nat Med. 2015. PMID: 26479923
Origins and impacts of new mammalian exons.
Merkin JJ, Chen P, Alexis MS, Hautaniemi SK, Burge CB. Merkin JJ, et al. Cell Rep. 2015 Mar 31;10(12):1992-2005. doi: 10.1016/j.celrep.2015.02.058. Epub 2015 Mar 19. Cell Rep. 2015. PMID: 25801031 Free PMC article.
Rational design of a SOCS1-edited tumor-infiltrating lymphocyte therapy using CRISPR/Cas9 screens.
Schlabach MR, Lin S, Collester ZR, Wrocklage C, Shenker S, Calnan C, Xu T, Gannon HS, Williams LJ, Thompson F, Dunbar PR, LaMothe RA, Garrett TE, Colletti N, Hohmann AF, Tubo NJ, Bullock CP, Le Mercier I, Sofjan K, Merkin JJ, Keegan S, Kryukov GV, Dugopolski C, Stegmeier F, Wong K, Sharp FA, Cadzow L, Benson MJ. Schlabach MR, et al. Among authors: merkin jj. J Clin Invest. 2023 Dec 15;133(24):e163096. doi: 10.1172/JCI163096. J Clin Invest. 2023. PMID: 38099496 Free PMC article.
Paradoxical Roles of Elongation Factor-2 Kinase in Stem Cell Survival.
Liao Y, Chu HP, Hu Z, Merkin JJ, Chen J, Liu Z, Degenhardt K, White E, Ryazanov AG. Liao Y, et al. Among authors: merkin jj. J Biol Chem. 2016 Sep 9;291(37):19545-57. doi: 10.1074/jbc.M116.724856. Epub 2016 Jul 27. J Biol Chem. 2016. PMID: 27466362 Free PMC article.
Germline quality control: eEF2K stands guard to eliminate defective oocytes.
Chu HP, Liao Y, Novak JS, Hu Z, Merkin JJ, Shymkiv Y, Braeckman BP, Dorovkov MV, Nguyen A, Clifford PM, Nagele RG, Harrison DE, Ellis RE, Ryazanov AG. Chu HP, et al. Among authors: merkin jj. Dev Cell. 2014 Mar 10;28(5):561-572. doi: 10.1016/j.devcel.2014.01.027. Epub 2014 Feb 27. Dev Cell. 2014. PMID: 24582807 Free PMC article.
26 results