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Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis.
Wagschal A, Najafi-Shoushtari SH, Wang L, Goedeke L, Sinha S, deLemos AS, Black JC, Ramírez CM, Li Y, Tewhey R, Hatoum I, Shah N, Lu Y, Kristo F, Psychogios N, Vrbanac V, Lu YC, Hla T, de Cabo R, Tsang JS, Schadt E, Sabeti PC, Kathiresan S, Cohen DE, Whetstine J, Chung RT, Fernández-Hernando C, Kaplan LM, Bernards A, Gerszten RE, Näär AM. Wagschal A, et al. Among authors: naar am. Nat Med. 2015 Nov;21(11):1290-7. doi: 10.1038/nm.3980. Epub 2015 Oct 26. Nat Med. 2015. PMID: 26501192 Free PMC article.
An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis.
Yang F, Vought BW, Satterlee JS, Walker AK, Jim Sun ZY, Watts JL, DeBeaumont R, Saito RM, Hyberts SG, Yang S, Macol C, Iyer L, Tjian R, van den Heuvel S, Hart AC, Wagner G, Näär AM. Yang F, et al. Among authors: naar am. Nature. 2006 Aug 10;442(7103):700-4. doi: 10.1038/nature04942. Epub 2006 Jun 21. Nature. 2006. PMID: 16799563
A nuclear receptor-like pathway regulating multidrug resistance in fungi.
Thakur JK, Arthanari H, Yang F, Pan SJ, Fan X, Breger J, Frueh DP, Gulshan K, Li DK, Mylonakis E, Struhl K, Moye-Rowley WS, Cormack BP, Wagner G, Näär AM. Thakur JK, et al. Among authors: naar am. Nature. 2008 Apr 3;452(7187):604-9. doi: 10.1038/nature06836. Nature. 2008. PMID: 18385733
Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.
Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, Boss O, Hirsch ML, Ribich S, Smith JJ, Israelian K, Westphal CH, Rodgers JT, Shioda T, Elson SL, Mulligan P, Najafi-Shoushtari H, Black JC, Thakur JK, Kadyk LC, Whetstine JR, Mostoslavsky R, Puigserver P, Li X, Dyson NJ, Hart AC, Näär AM. Walker AK, et al. Among authors: naar am. Genes Dev. 2010 Jul 1;24(13):1403-17. doi: 10.1101/gad.1901210. Genes Dev. 2010. PMID: 20595232 Free PMC article.
A SIRT1-LSD1 corepressor complex regulates Notch target gene expression and development.
Mulligan P, Yang F, Di Stefano L, Ji JY, Ouyang J, Nishikawa JL, Toiber D, Kulkarni M, Wang Q, Najafi-Shoushtari SH, Mostoslavsky R, Gygi SP, Gill G, Dyson NJ, Näär AM. Mulligan P, et al. Among authors: naar am. Mol Cell. 2011 Jun 10;42(5):689-99. doi: 10.1016/j.molcel.2011.04.020. Epub 2011 May 19. Mol Cell. 2011. PMID: 21596603 Free PMC article.
MicroRNAs in metabolism and metabolic diseases.
Rottiers V, Najafi-Shoushtari SH, Kristo F, Gurumurthy S, Zhong L, Li Y, Cohen DE, Gerszten RE, Bardeesy N, Mostoslavsky R, Näär AM. Rottiers V, et al. Among authors: naar am. Cold Spring Harb Symp Quant Biol. 2011;76:225-33. doi: 10.1101/sqb.2011.76.011049. Epub 2011 Dec 12. Cold Spring Harb Symp Quant Biol. 2011. PMID: 22156303 Free PMC article.
MicroRNAs in metabolism and metabolic disorders.
Rottiers V, Näär AM. Rottiers V, et al. Among authors: naar am. Nat Rev Mol Cell Biol. 2012 Mar 22;13(4):239-50. doi: 10.1038/nrm3313. Nat Rev Mol Cell Biol. 2012. PMID: 22436747 Free PMC article. Review.
Pharmacological inhibition of a microRNA family in nonhuman primates by a seed-targeting 8-mer antimiR.
Rottiers V, Obad S, Petri A, McGarrah R, Lindholm MW, Black JC, Sinha S, Goody RJ, Lawrence MS, deLemos AS, Hansen HF, Whittaker S, Henry S, Brookes R, Najafi-Shoushtari SH, Chung RT, Whetstine JR, Gerszten RE, Kauppinen S, Näär AM. Rottiers V, et al. Among authors: naar am. Sci Transl Med. 2013 Nov 20;5(212):212ra162. doi: 10.1126/scitranslmed.3006840. Sci Transl Med. 2013. PMID: 24259050 Free PMC article.
60 results