Das J - Search Results

1

ApoE4-specific Misfolded Intermediate Identified by Molecular Dynamics Simulations.

Williams B 2nd, Convertino M, Das J, Dokholyan NV. Williams B 2nd, et al. Among authors: das j. PLoS Comput Biol. 2015 Oct 27;11(10):e1004359. doi: 10.1371/journal.pcbi.1004359. eCollection 2015 Oct. PLoS Comput Biol. 2015. PMID: 26506597 Free PMC article.

2

Potentiator ivacaftor abrogates pharmacological correction of ΔF508 CFTR in cystic fibrosis.

Cholon DM, Quinney NL, Fulcher ML, Esther CR Jr, Das J, Dokholyan NV, Randell SH, Boucher RC, Gentzsch M. Cholon DM, et al. Among authors: das j. Sci Transl Med. 2014 Jul 23;6(246):246ra96. doi: 10.1126/scitranslmed.3008680. Sci Transl Med. 2014. PMID: 25101886 Free PMC article.

3

Protein Destabilization as a Common Factor in Diverse Inherited Disorders.

Redler RL, Das J, Diaz JR, Dokholyan NV. Redler RL, et al. Among authors: das j. J Mol Evol. 2016 Jan;82(1):11-6. doi: 10.1007/s00239-015-9717-5. Epub 2015 Nov 19. J Mol Evol. 2016. PMID: 26584803 Free PMC article.

4

A modified PATH algorithm rapidly generates transition states comparable to those found by other well established algorithms.

Chandrasekaran SN, Das J, Dokholyan NV, Carter CW Jr. Chandrasekaran SN, et al. Among authors: das j. Struct Dyn. 2016 Feb 24;3(1):012101. doi: 10.1063/1.4941599. eCollection 2016 Jan. Struct Dyn. 2016. PMID: 26958584 Free PMC article.

5

Pharmacological Chaperones: Design and Development of New Therapeutic Strategies for the Treatment of Conformational Diseases.

Convertino M, Das J, Dokholyan NV. Convertino M, et al. Among authors: das j. ACS Chem Biol. 2016 Jun 17;11(6):1471-89. doi: 10.1021/acschembio.6b00195. Epub 2016 Apr 28. ACS Chem Biol. 2016. PMID: 27097127 Review.

6

Restoration of R117H CFTR folding and function in human airway cells through combination treatment with VX-809 and VX-770.

Gentzsch M, Ren HY, Houck SA, Quinney NL, Cholon DM, Sopha P, Chaudhry IG, Das J, Dokholyan NV, Randell SH, Cyr DM. Gentzsch M, et al. Among authors: das j. Am J Physiol Lung Cell Mol Physiol. 2016 Sep 1;311(3):L550-9. doi: 10.1152/ajplung.00186.2016. Epub 2016 Jul 8. Am J Physiol Lung Cell Mol Physiol. 2016. PMID: 27402691 Free PMC article.

7

Transmembrane helical interactions in the CFTR channel pore.

Das J, Aleksandrov AA, Cui L, He L, Riordan JR, Dokholyan NV. Das J, et al. PLoS Comput Biol. 2017 Jun 22;13(6):e1005594. doi: 10.1371/journal.pcbi.1005594. eCollection 2017 Jun. PLoS Comput Biol. 2017. PMID: 28640808 Free PMC article.

8

Molecular Mechanisms of the R61T Mutation in Apolipoprotein E4: A Dynamic Rescue.

Williams B 2nd, Convertino M, Das J, Dokholyan NV. Williams B 2nd, et al. Among authors: das j. Biophys J. 2017 Nov 21;113(10):2192-2198. doi: 10.1016/j.bpj.2017.08.026. Epub 2017 Sep 12. Biophys J. 2017. PMID: 28916386 Free PMC article.

9

Microcalorimetry reveals multi-state thermal denaturation of G. stearothermophilus tryptophanyl-tRNA synthetase.

Chandrasekaran SN, Das J, Dokholyan NV, Carter CW Jr. Chandrasekaran SN, et al. Among authors: das j. Struct Dyn. 2023 Jul 18;10(4):044301. doi: 10.1063/4.0000181. eCollection 2023 Jul. Struct Dyn. 2023. PMID: 37476003 Free PMC article.

10

Leveraging high-throughput screening data, deep neural networks, and conditional generative adversarial networks to advance predictive toxicology.

Green AJ, Mohlenkamp MJ, Das J, Chaudhari M, Truong L, Tanguay RL, Reif DM. Green AJ, et al. Among authors: das j. PLoS Comput Biol. 2021 Jul 2;17(7):e1009135. doi: 10.1371/journal.pcbi.1009135. eCollection 2021 Jul. PLoS Comput Biol. 2021. PMID: 34214078 Free PMC article.

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