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Targeted massively parallel sequencing of a panel of putative breast cancer susceptibility genes in a large cohort of multiple-case breast and ovarian cancer families.
Li J, Meeks H, Feng BJ, Healey S, Thorne H, Makunin I, Ellis J; kConFab Investigators; Campbell I, Southey M, Mitchell G, Clouston D, Kirk J, Goldgar D, Chenevix-Trench G. Li J, et al. Among authors: clouston d. J Med Genet. 2016 Jan;53(1):34-42. doi: 10.1136/jmedgenet-2015-103452. Epub 2015 Nov 3. J Med Genet. 2016. PMID: 26534844 Free PMC article.
Decreased prostate cancer-specific survival of men with BRCA2 mutations from multiple breast cancer families.
Thorne H, Willems AJ, Niedermayr E, Hoh IM, Li J, Clouston D, Mitchell G, Fox S, Hopper JL; Kathleen Cunningham Consortium for Research in Familial Breast Cancer Consortium; Bolton D. Thorne H, et al. Among authors: clouston d. Cancer Prev Res (Phila). 2011 Jul;4(7):1002-10. doi: 10.1158/1940-6207.CAPR-10-0397. Cancer Prev Res (Phila). 2011. PMID: 21733824
Patient-derived xenografts reveal that intraductal carcinoma of the prostate is a prominent pathology in BRCA2 mutation carriers with prostate cancer and correlates with poor prognosis.
Risbridger GP, Taylor RA, Clouston D, Sliwinski A, Thorne H, Hunter S, Li J, Mitchell G, Murphy D, Frydenberg M, Pook D, Pedersen J, Toivanen R, Wang H, Papargiris M, Lawrence MG, Bolton DM. Risbridger GP, et al. Among authors: clouston d. Eur Urol. 2015 Mar;67(3):496-503. doi: 10.1016/j.eururo.2014.08.007. Epub 2014 Aug 22. Eur Urol. 2015. PMID: 25154392
Searching for candidate genes in familial BRCAX mutation carriers with prostate cancer.
Hunter SM, Rowley SM, Clouston D; KCon Fab Investigators; Li J, Lupat R, Krishnananthan N, Risbridger G, Taylor R, Bolton D, Campbell IG, Thorne H. Hunter SM, et al. Among authors: clouston d. Urol Oncol. 2016 Mar;34(3):120.e9-16. doi: 10.1016/j.urolonc.2015.10.009. Epub 2015 Nov 14. Urol Oncol. 2016. PMID: 26585945
Germline BRCA2 mutations drive prostate cancers with distinct evolutionary trajectories.
Taylor RA, Fraser M, Livingstone J, Espiritu SM, Thorne H, Huang V, Lo W, Shiah YJ, Yamaguchi TN, Sliwinski A, Horsburgh S, Meng A, Heisler LE, Yu N, Yousif F, Papargiris M, Lawrence MG, Timms L, Murphy DG, Frydenberg M, Hopkins JF, Bolton D, Clouston D, McPherson JD, van der Kwast T, Boutros PC, Risbridger GP, Bristow RG. Taylor RA, et al. Among authors: clouston d. Nat Commun. 2017 Jan 9;8:13671. doi: 10.1038/ncomms13671. Nat Commun. 2017. PMID: 28067867 Free PMC article.
Intraductal carcinoma of the prostate can evade androgen deprivation, with emergence of castrate-tolerant cells.
Porter LH, Hashimoto K, Lawrence MG, Pezaro C, Clouston D, Wang H, Papargiris M, Thorne H, Li J; kConFab; Ryan A, Norden S, Moon D, Bolton DM, Sengupta S, Frydenberg M, Murphy DG, Risbridger GP, Taylor RA. Porter LH, et al. Among authors: clouston d. BJU Int. 2018 Jun;121(6):971-978. doi: 10.1111/bju.14043. Epub 2017 Oct 26. BJU Int. 2018. PMID: 28977728
Mixed ductal-lobular carcinomas: evidence for progression from ductal to lobular morphology.
McCart Reed AE, Kutasovic JR, Nones K, Saunus JM, Da Silva L, Newell F, Kazakoff S, Melville L, Jayanthan J, Vargas AC, Reid LE, Beesley J, Chen XQ, Patch AM, Clouston D, Porter A, Evans E, Pearson JV, Chenevix-Trench G, Cummings MC, Waddell N, Lakhani SR, Simpson PT. McCart Reed AE, et al. Among authors: clouston d. J Pathol. 2018 Apr;244(4):460-468. doi: 10.1002/path.5040. Epub 2018 Mar 9. J Pathol. 2018. PMID: 29344954 Free PMC article.
Tumor immune microenvironment of primary prostate cancer with and without germline mutations in homologous recombination repair genes.
Trigos AS, Pasam A, Banks P, Wallace R, Guo C, Keam S, Thorne H; kConFab; Mitchell C, Lade S, Clouston D, Hakansson A, Liu Y, Blyth B, Murphy D, Lawrentschuk N, Bolton D, Moon D, Darcy P, Haupt Y, Williams SG, Castro E, Olmos D, Goode D, Neeson P, Sandhu S. Trigos AS, et al. Among authors: clouston d. J Immunother Cancer. 2022 Jun;10(6):e003744. doi: 10.1136/jitc-2021-003744. J Immunother Cancer. 2022. PMID: 35764368 Free PMC article.
59 results