Dinkova-Kostova AT - Search Results

1

The spatiotemporal regulation of the Keap1-Nrf2 pathway and its importance in cellular bioenergetics.

Dinkova-Kostova AT, Baird L, Holmström KM, Meyer CJ, Abramov AY. Dinkova-Kostova AT, et al. Biochem Soc Trans. 2015 Aug;43(4):602-10. doi: 10.1042/BST20150003. Epub 2015 Aug 3. Biochem Soc Trans. 2015. PMID: 26551700 Free PMC article.

2

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants.

Dinkova-Kostova AT, Holtzclaw WD, Cole RN, Itoh K, Wakabayashi N, Katoh Y, Yamamoto M, Talalay P. Dinkova-Kostova AT, et al. Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11908-13. doi: 10.1073/pnas.172398899. Epub 2002 Aug 22. Proc Natl Acad Sci U S A. 2002. PMID: 12193649 Free PMC article.

3

Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers.

Wakabayashi N, Dinkova-Kostova AT, Holtzclaw WD, Kang MI, Kobayashi A, Yamamoto M, Kensler TW, Talalay P. Wakabayashi N, et al. Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2040-5. doi: 10.1073/pnas.0307301101. Epub 2004 Feb 5. Proc Natl Acad Sci U S A. 2004. PMID: 14764894 Free PMC article.

4

The role of Keap1 in cellular protective responses.

Dinkova-Kostova AT, Holtzclaw WD, Kensler TW. Dinkova-Kostova AT, et al. Chem Res Toxicol. 2005 Dec;18(12):1779-91. doi: 10.1021/tx050217c. Chem Res Toxicol. 2005. PMID: 16359168 Review. No abstract available.

5

Activation of the NRF2 signaling pathway by copper-mediated redox cycling of para- and ortho-hydroquinones.

Wang XJ, Hayes JD, Higgins LG, Wolf CR, Dinkova-Kostova AT. Wang XJ, et al. Chem Biol. 2010 Jan 29;17(1):75-85. doi: 10.1016/j.chembiol.2009.12.013. Chem Biol. 2010. PMID: 20142043

6

NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector.

Dinkova-Kostova AT, Talalay P. Dinkova-Kostova AT, et al. Arch Biochem Biophys. 2010 Sep 1;501(1):116-23. doi: 10.1016/j.abb.2010.03.019. Epub 2010 Mar 31. Arch Biochem Biophys. 2010. PMID: 20361926 Free PMC article. Review.

7

Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway.

Hayes JD, McMahon M, Chowdhry S, Dinkova-Kostova AT. Hayes JD, et al. Antioxid Redox Signal. 2010 Dec 1;13(11):1713-48. doi: 10.1089/ars.2010.3221. Epub 2010 Aug 14. Antioxid Redox Signal. 2010. PMID: 20446772 Review.

8

An exceptionally potent inducer of cytoprotective enzymes: elucidation of the structural features that determine inducer potency and reactivity with Keap1.

Dinkova-Kostova AT, Talalay P, Sharkey J, Zhang Y, Holtzclaw WD, Wang XJ, David E, Schiavoni KH, Finlayson S, Mierke DF, Honda T. Dinkova-Kostova AT, et al. J Biol Chem. 2010 Oct 29;285(44):33747-55. doi: 10.1074/jbc.M110.163485. Epub 2010 Aug 26. J Biol Chem. 2010. PMID: 20801881 Free PMC article.

9

Induction of the Keap1/Nrf2/ARE pathway by oxidizable diphenols.

Dinkova-Kostova AT, Wang XJ. Dinkova-Kostova AT, et al. Chem Biol Interact. 2011 Jun 30;192(1-2):101-6. doi: 10.1016/j.cbi.2010.09.010. Epub 2010 Sep 21. Chem Biol Interact. 2011. PMID: 20846517

10

The cytoprotective role of the Keap1-Nrf2 pathway.

Baird L, Dinkova-Kostova AT. Baird L, et al. Arch Toxicol. 2011 Apr;85(4):241-72. doi: 10.1007/s00204-011-0674-5. Epub 2011 Mar 2. Arch Toxicol. 2011. PMID: 21365312 Review.

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